UniProt P09871
Complement C1s subcomponent (P09871)
Complement C1s subcomponent (UniProt P09871), EC 3.4.21.42: 23 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P09871
- Protein
- Complement C1s subcomponent
- EC
- 3.4.21.42
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 40 · 6 records with a druggable one
Structures
24 records of P09871 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ELV | Crystal structure of the catalytic domain of human complement C1S protease | x-ray diffraction | A | — | — |
| 1ELV | Crystal structure of the catalytic domain of human complement C1S protease | x-ray diffraction | A | — | — |
| 1NZI | Crystal Structure of the CUB1-EGF Interaction Domain of Complement Protease C1s | x-ray diffraction | A, B | — | — |
| 1NZI | Crystal structure of the CUB1-EGF interaction domain of complement protease C1S | x-ray diffraction | A, B | — | — |
| 4J1Y | The X-ray crystal structure of human complement protease C1s zymogen | x-ray diffraction | A, B | — | — |
| 4J1Y | The X-ray crystal structure of human complement protease C1S zymogen | x-ray diffraction | A, B | — | — |
| 4LMF | C1s CUB1-EGF-CUB2 | x-ray diffraction | A, B, C, D | — | — |
| 4LMF | C1S CUB1-EGF-CUB2 | x-ray diffraction | A, B, C, D | — | — |
| 4LOR | C1s CUB1-EGF-CUB2 in complex with a collagen-like peptide from C1q | x-ray diffraction | A | — | — |
| 4LOR | C1S CUB1-EGF-CUB2 in complex with a collagen-like peptide from C1Q | x-ray diffraction | A | — | — |
| 4LOS | C1s CUB2-CCP1 | x-ray diffraction | A | — | — |
| 4LOS | C1S CUB2-CCP1 | x-ray diffraction | A | — | — |
| 4LOT | C1s CUB2-CCP1-CCP2 | x-ray diffraction | A | — | — |
| 4LOT | C1S CUB2-CCP1-CCP2 | x-ray diffraction | A | — | — |
| 5UBM | Crystal structure of human C1s in complex with inhibitor gigastasin | x-ray diffraction | A, B | NAG | 5 (best 0.77) |
| 5UBM | Crystal structure of human C1S in complex with inhibitor gigastasin | x-ray diffraction | A, B | NAG | — |
| 6F1C | C1rC1s complex | x-ray diffraction | D, B | NAG, CA, NA | 10 (best 0.71) |
| 6F1C | C1RC1S complex | x-ray diffraction | D, B | NAG, CA, NA | — |
| 6F1H | C1rC1s complex | x-ray diffraction | D, B | NAG, CA, NA | 10 (best 0.76) |
| 6F1H | C1RC1S complex | x-ray diffraction | D, B | NAG, CA, NA | — |
| 8GMN | Crystal structure of human C1s in complex with inhibitor | x-ray diffraction | A, B, C, D | ZWK, SO4 | 9 (best 0.74) |
| 8TYP | Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide | x-ray diffraction | A | NAG, FUC, SQT | 2 (best 0.51) |
| 8W18 | The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms | x-ray diffraction | B, A | — | 4 (best 0.75) |
| P09871 | AlphaFold monomer V2.0 prediction for complement C1S subcomponent (P09871) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- CA · Calcium ion · in 4 records
- NA · Sodium ion · in 4 records
- FUC · alpha-L-fucopyranose · in 1 record
- SO4 · Sulfate ion · in 1 record
- SQT · 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide · in 1 record
- ZWK · [4-(1-aminophthalazin-6-yl)piperazin-1-yl](2-methylphenyl)methanone · in 1 record
Experiment against prediction
- 1ELV chain A against the predicted model P09871: TM-score 0.98, RMSD 1.08 Å
- 1ELV chain A against the predicted model P09871: TM-score 0.98, RMSD 1.08 Å
- 8GMN chain B against the predicted model P09871: TM-score 0.98, RMSD 1.14 Å
- 8GMN chain A against the predicted model P09871: TM-score 0.98, RMSD 1.15 Å
- 8TYP chain A against the predicted model P09871: TM-score 0.98, RMSD 1.22 Å
- 4LOS chain A against the predicted model P09871: TM-score 0.97, RMSD 1.06 Å
- 4LOS chain A against the predicted model P09871: TM-score 0.97, RMSD 1.06 Å
- 8GMN chain D against the predicted model P09871: TM-score 0.97, RMSD 1.59 Å
- 5UBM chain A against the predicted model P09871: TM-score 0.97, RMSD 1.49 Å
- 5UBM chain A against the predicted model P09871: TM-score 0.97, RMSD 1.49 Å
Elsewhere
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