UniProt P08887
Interleukin-6 receptor subunit alpha (P08887)
Interleukin-6 receptor subunit alpha (UniProt P08887): 16 experimental structures on GenesisL1, 3 ligands bound, 24 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P08887
- Protein
- Interleukin-6 receptor subunit alpha
- Experimental structures
- 16
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 24 · 4 records with a druggable one
Structures
16 records of P08887 in the MolNFT archive: 16 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1N26 | Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain | x-ray diffraction | A | — | — |
| 1N26 | Crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain | x-ray diffraction | A | — | — |
| 1P9M | Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex | x-ray diffraction | C | — | — |
| 1P9M | Crystal structure of the hexameric human il-6/IL-6 alpha RECEPTOR/GP130 complex | x-ray diffraction | C | — | — |
| 2ARW | The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6… | solution nmr | A | — | — |
| 2ARW | The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6… | solution nmr | A | — | — |
| 5FUC | Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80… | x-ray diffraction | C, D | NAG | — |
| 5FUC | Biophysical and cellular characterisation of a junctional epitope antibody that locks il-6 and GP80… | x-ray diffraction | C, D | — | — |
| 7DC8 | Crystal structure of Switch Ab Fab and hIL6R in complex with ATP | x-ray diffraction | C, F | ATP, SO4 | 5 (best 0.72) |
| 7DC8 | Crystal structure of switch ab Fab and HIL6R in complex with ATP | x-ray diffraction | C, F | ATP, SO4 | — |
| 8D82 | Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular… | electron microscopy | C, G | NAG | 9 (best 0.81) |
| 8IOW | Cryo-EM structure of the sarilumab Fab/IL-6R complex | electron microscopy | I, D2 | NAG | 1 (best 0.46) |
| 8J6F | Cryo-EM structure of the Tocilizumab Fab/IL-6R complex | electron microscopy | I, B | NAG | 1 (best 0.31) |
| 8QY5 | Structure of interleukin 6. | electron microscopy | C, F | — | 3 (best 0.76) |
| 8QY6 | Structure of interleukin 6 (gp130 P496L mutant). | electron microscopy | C, F | — | 5 (best 0.76) |
| P08887 | AlphaFold monomer V2.0 prediction for interleukin-6 receptor subunit alpha (P08887) | — | — | — |
Ligands
Elsewhere
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