UniProt P08311
Cathepsin G, C-terminal truncated form (P08311)
Cathepsin G, C-terminal truncated form (UniProt P08311), EC 3.4.21.20: 19 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 78 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08311
- Protein
- Cathepsin G, C-terminal truncated form
- EC
- 3.4.21.20
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 78 · 10 records with a druggable one
Structures
20 records of P08311 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AU8 | Human cathepsin G | x-ray diffraction | A | 0H8 | 1 (best 0.49) |
| 1AU8 | Human cathepsin G | x-ray diffraction | A | — | — |
| 1CGH | Human cathepsin G | x-ray diffraction | A | — | — |
| 1CGH | Human cathepsin G | x-ray diffraction | A | — | — |
| 1KYN | Cathepsin-G | x-ray diffraction | A, B | — | — |
| 1KYN | CATHEPSIN-G | x-ray diffraction | A, B | — | — |
| 1T32 | A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in… | x-ray diffraction | A | — | — |
| 1T32 | A dual inhibitor of the leukocyte proteases cathepsin G and chymase with therapeutic efficacy in… | x-ray diffraction | A | — | — |
| 6VTM | Human Cathepsin-G Inhibited by S. aureus EapH1 | x-ray diffraction | A, C, D, G | SO4 | 9 (best 0.84) |
| 6VTM | Human cathepsin-G inhibited by S. aureus EAPH1 | x-ray diffraction | A, C, D, G | SO4 | — |
| 8D4S | Crystal Structure of Cathepsin G Inhibited by Eap1 from S. aureus | x-ray diffraction | A, C, E, G | NAG | 9 (best 0.57) |
| 8D4V | Crystal Structure of Cathepsin G Inhibited by Eap2 from S. aureus | x-ray diffraction | A, C | SO4 | 6 (best 0.69) |
| 8D7I | Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap1 from S. aureus | x-ray diffraction | C, F, I, L, O, R | — | 11 (best 0.67) |
| 8D7K | Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus | x-ray diffraction | C, F, I, L | — | 10 (best 0.83) |
| 8G24 | Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 5.5 | x-ray diffraction | A | — | 2 (best 0.64) |
| 8G25 | Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5 | x-ray diffraction | A, F, I | — | 10 (best 0.79) |
| 8G26 | Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 8.5 | x-ray diffraction | A | — | 2 (best 0.65) |
| 9ASX | BIFUNCTIONAL INHIBITION OF NEUTROPHIL ELASTASE AND CATHEPSIN G by Eap3 of S. aureus | x-ray diffraction | A | NAG | 2 (best 0.66) |
| 9ATK | BIFUNCTIONAL INHIBITION OF NEUTROPHIL ELASTASE AND CATHEPSIN G by Eap4 of S. aureus | x-ray diffraction | E, H, B, K | NAG | 16 (best 0.82) |
| P08311 | AlphaFold monomer V2.0 prediction for cathepsin G (P08311) | predicted | A | — | — |
Ligands
Experiment against prediction
- 9ASX chain A against the predicted model P08311: TM-score 1.00, RMSD 0.39 Å
- 6VTM chain D against the predicted model P08311: TM-score 1.00, RMSD 0.40 Å
- 6VTM chain D against the predicted model P08311: TM-score 1.00, RMSD 0.40 Å
- 6VTM chain G against the predicted model P08311: TM-score 0.99, RMSD 0.43 Å
- 6VTM chain G against the predicted model P08311: TM-score 0.99, RMSD 0.43 Å
- 6VTM chain A against the predicted model P08311: TM-score 0.99, RMSD 0.42 Å
- 6VTM chain A against the predicted model P08311: TM-score 0.99, RMSD 0.42 Å
- 6VTM chain C against the predicted model P08311: TM-score 0.99, RMSD 0.43 Å
- 6VTM chain C against the predicted model P08311: TM-score 0.99, RMSD 0.43 Å
- 8D7K chain I against the predicted model P08311: TM-score 0.99, RMSD 0.42 Å
Elsewhere
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