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Ligand · OHH

OHH · 2-[3-({methyl[1-(2-naphthoyl)piperidin-4-yl]amino}carbonyl)-2-naphthyl]-1-(1-naphthyl)-2-oxoethylphosphonic acid

OHH, 2-[3-({methyl[1-(2-naphthoyl)piperidin-4-yl]amino}carbonyl)-2-naphthyl]-1-(1-naphthyl)-2-oxoethylphosphonic acid (C40 H35 N2 O6 P, 670.7 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding…

Component
OHH
Formula
C40 H35 N2 O6 P
Class
ligand
Structures
4
PDB entries
2

Binding sites

OHH in 4 structures; the first of them:

  • 1T31 · A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic… · OHH A901 · binds LYS40, CYS42, HIS57, TYR94, THR96, LEU99, ASP102, ALA190 and 12 more
  • 1T32 · A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic… · OHH A901 · binds ARG41, CYS42, HIS57, ILE99, ILE171, PHE172, ALA190, PHE191 and 11 more
  • 1T31 · A dual inhibitor of the leukocyte proteases cathepsin G and chymase with therapeutic… · OHH A901 · binds LYS40, CYS42, HIS57, TYR94, THR96, LEU99, ASP102, ALA190 and 12 more
  • 1T32 · A dual inhibitor of the leukocyte proteases cathepsin G and chymase with therapeutic… · OHH A901 · binds ARG41, CYS42, HIS57, ILE99, ILE171, PHE172, ALA190, PHE191 and 11 more

Residues it binds most

SER 4, GLY 4, LYS 4, ALA 4, ASP 4, PHE 4, TYR 4, ARG 4, CYS 4, HIS 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • CO · Cobalt (II) ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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