UniProt P08179
Glycinamide ribonucleotide transformylase (P08179)
Glycinamide ribonucleotide transformylase (UniProt P08179), EC 2.1.2.2: 18 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08179
- Protein
- Glycinamide ribonucleotide transformylase
- EC
- 2.1.2.2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 59 · 13 records with a druggable one
Structures
19 records of P08179 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C2T | New insights into inhibitor design from the crystal structure and NMR studies of E. COLI gar… | x-ray diffraction | A, B | NHS, GAR | 4 (best 0.68) |
| 1C2T | New insights into inhibitor design from the crystal structure and NMR studies of E. COLI gar… | x-ray diffraction | A, B | NHS, GAR | 4 (best 0.68) |
| 1C3E | New insights into inhibitor design from the crystal structure and NMR studies of E. COLI gar… | x-ray diffraction | A | NHR, GAR | 3 (best 0.65) |
| 1C3E | New insights into inhibitor design from the crystal structure and NMR studies of E. COLI gar… | x-ray diffraction | A | NHR, GAR | 3 (best 0.65) |
| 1CDD | Structures of apo and complexed escherichia COLI glycinamide ribonucleotide transformylase | x-ray diffraction | A, B | PO4 | 3 (best 0.42) |
| 1CDD | Structures of apo and complexed escherichia COLI glycinamide ribonucleotide transformylase | x-ray diffraction | A, B | PO4 | 3 (best 0.42) |
| 1CDE | Structures of apo and complexed escherichia COLI glycinamide ribonucleotide transformylase | x-ray diffraction | A, B, C, D | GAR, DZF | 4 (best 0.65) |
| 1CDE | Structures of apo and complexed escherichia COLI glycinamide ribonucleotide transformylase | x-ray diffraction | A, B, C, D | GAR, DZF | 4 (best 0.65) |
| 1GAR | Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of… | x-ray diffraction | A, B | U89 | 3 (best 0.60) |
| 1GAR | Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of… | x-ray diffraction | A, B | U89 | 3 (best 0.60) |
| 1GRC | Crystal structure of glycinamide ribonucleotide transformylase from escherichia COLI at 3.0… | x-ray diffraction | A, B | PO4 | 3 (best 0.38) |
| 1GRC | Crystal structure of glycinamide ribonucleotide transformylase from escherichia COLI at 3.0… | x-ray diffraction | A, B | PO4 | 3 (best 0.38) |
| 1JKX | Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of… | x-ray diffraction | A, B, C, D | 138 | 7 (best 0.63) |
| 1JKX | Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of… | x-ray diffraction | A, B, C, D | 138 | 7 (best 0.63) |
| 2GAR | A pH-dependent stablization of an active site loop observed from low and high pH crystal structures… | x-ray diffraction | A | PO4 | 1 (best 0.35) |
| 2GAR | A pH-dependent stablization of an active site loop observed from low and high pH crystal structures… | x-ray diffraction | A | PO4 | 1 (best 0.35) |
| 3GAR | A pH-dependent stablization of an active site loop observed from low and high pH crystal structures… | x-ray diffraction | A | PO4 | 1 (best 0.59) |
| 3GAR | A pH-dependent stablization of an active site loop observed from low and high pH crystal structures… | x-ray diffraction | A | PO4 | 1 (best 0.59) |
| P08179 | AlphaFold monomer V2.0 prediction for phosphoribosylglycinamide formyltransferase (P08179) | predicted | A | — | 1 (best 0.63) |
Ligands
- PO4 · Phosphate ion · in 8 records
- GAR · Glycinamide ribonucleotide · in 6 records
- 138 · N-[5'-O-phosphono-ribofuranosyl]-2-[2-hydroxy-2-[4-[glutamic acid]-N-carbonylphenyl]-3-[2-amino-4-hydroxy-quinazolin-6-yl]-propanylamino]-acetamide · in 2 records
- DZF · 5-deazafolic acid · in 2 records
- NHR · 2-{4-[2-(2-amino-4-hydroxy-quinazolin-6-yl)-1-carboxy-ethyl]-benzoylamino}-pentanedioic acid · in 2 records
- NHS · 10-formyl-5,8,10-trideazafolic acid · in 2 records
- U89 · N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-4-pyrimidinyl)-propyl]-[2-((2-oxo-2-((4-phosphoriboxy)-butyl)-amino)-ethyl)-thio-acetyl]-amino]benzoyl]-1-glutamic acid · in 2 records
Experiment against prediction
- 1C2T chain B against the predicted model P08179: TM-score 0.99, RMSD 0.42 Å
- 1C2T chain B against the predicted model P08179: TM-score 0.99, RMSD 0.42 Å
- 1C3E chain A against the predicted model P08179: TM-score 0.99, RMSD 0.44 Å
- 1C3E chain A against the predicted model P08179: TM-score 0.99, RMSD 0.44 Å
- 1C2T chain A against the predicted model P08179: TM-score 0.99, RMSD 0.44 Å
- 1C2T chain A against the predicted model P08179: TM-score 0.99, RMSD 0.44 Å
- 1CDE chain D against the predicted model P08179: TM-score 0.99, RMSD 0.58 Å
- 1CDE chain D against the predicted model P08179: TM-score 0.99, RMSD 0.58 Å
- 1CDE chain A against the predicted model P08179: TM-score 0.99, RMSD 0.58 Å
- 1CDE chain A against the predicted model P08179: TM-score 0.99, RMSD 0.58 Å
Elsewhere
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