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Ligand · DZF

DZF · 5-deazafolic acid

DZF, 5-deazafolic acid (C20 H20 N6 O6, 440.4 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
DZF
Formula
C20 H20 N6 O6
Class
ligand
Structures
6
PDB entries
3

Binding sites

DZF in 6 structures; the first of them:

  • 1CDE · Structures of apo and complexed escherichia COLI glycinamide ribonucleotide transformylase · DZF A225 · binds LEU85, PHE88, MET89, ARG90, ILE91, LEU92, VAL97, ASN106 and 9 more
  • 1DYH · Isomorphous crystal structures of escherichia COLI dihydrofolate reductase complexed with… · DZF A161 · binds ILE5, ALA6, ALA7, ASP27, LEU28, ALA29, TRP30, PHE31 and 10 more
  • 2DHF · Crystal structures of recombinant human dihydrofolate reductase complexed with folate and… · DZF A187 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, ARG32, PHE34 and 11 more
  • 1CDE · Structures of apo and complexed escherichia COLI glycinamide ribonucleotide transformylase · DZF A225 · binds LEU85, PHE88, MET89, ARG90, ILE91, LEU92, VAL97, ASN106 and 9 more
  • 1DYH · Isomorphous crystal structures of escherichia COLI dihydrofolate reductase complexed with… · DZF A161 · binds ILE5, ALA6, ALA7, ASP27, LEU28, ALA29, TRP30, PHE31 and 10 more
  • 2DHF · Crystal structures of recombinant human dihydrofolate reductase complexed with folate and… · DZF A187 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, ARG32, PHE34 and 11 more

Residues it binds most

LEU 16, ILE 16, ARG 16, THR 16, VAL 12, ASP 12, PHE 16, ALA 8, ASN 12, GLU 12 (residue and the binding sites it lines).

Found with

  • GAR · Glycinamide ribonucleotide
  • CA · Calcium ion
  • CL · Chloride ion

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