UniProt P08034
Gap junction beta-1 protein (P08034)
Gap junction beta-1 protein (UniProt P08034): 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 120 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08034
- Protein
- Gap junction beta-1 protein
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 120 · 6 records with a druggable one
Structures
10 records of P08034 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KK9 | Connexin 32 G12R N-Terminal Mutant, | solution nmr | A | — | — |
| 5KK9 | Connexin 32 G12R N-terminal mutant, | solution nmr | A | ACE | — |
| 7ZXM | cryo-EM structure of Connexin 32 gap junction channel | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.61) |
| 7ZXN | cryo-EM structure of Connexin 32 gap junction channel | electron microscopy | A, B, C, D, E, F | CLR | — |
| 7ZXQ | cryo-EM structure of Connexin 32 R22G mutation hemi channel | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.76) |
| 8QJF | Connexin-32 gap junction channel in complex with 2-aminoethoxydiphenyl borate | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M | CLR | 20 (best 0.78) |
| 8QJH | Connexin-32 gap junction channel in complex with mefloquine | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.54) |
| 8QK6 | Connexin-32 hemichannel upon addition of 2-aminoetoxydiphenyl borate | electron microscopy | A, B, C, D, E, F | CLR | 20 (best 0.76) |
| 8QKI | Connexin-32 hemichannel upon addition of mefloquine | electron microscopy | A, B, C, D, E, F | CLR | 20 (best 0.77) |
| P08034 | AlphaFold monomer V2.0 prediction for gap junction beta-1 protein (P08034) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8QJH chain D against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain B against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain L against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain A against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain F against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain C against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain E against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain G against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain I against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
- 8QJH chain K against the predicted model P08034: TM-score 0.96, RMSD 1.06 Å
Elsewhere
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