UniProt P07140
Acetylcholinesterase (P07140)
Acetylcholinesterase (UniProt P07140), EC 3.1.1.7: 9 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07140
- Protein
- Acetylcholinesterase
- EC
- 3.1.1.7
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 5 · 2 records with a druggable one
Structures
10 records of P07140 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DX4 | Ache from drosophila melanogaster complex with tacrine derivative 9… | x-ray diffraction | A | — | — |
| 1QO9 | Native acetylcholinesterase from drosophila melanogaster | x-ray diffraction | A | — | — |
| 1QON | Ache from drosophila melanogaster complex with tacrine derivative 9… | x-ray diffraction | A | — | — |
| 6XYS | Update of native acetylcholinesterase from Drosophila Melanogaster | x-ray diffraction | A | NAG, BMA, MAN, CL | — |
| 6XYS | Update of native acetylcholinesterase from drosophila melanogaster | x-ray diffraction | A | NAG, BMA, MAN, CL | — |
| 6XYU | Update of AChE from Drosophila Melanogaster complex with tacrine derivative… | x-ray diffraction | A | NAG, I40, IOD | 2 (best 0.78) |
| 6XYU | Update of ache from drosophila melanogaster complex with tacrine derivative… | x-ray diffraction | A | NAG, I40, IOD | — |
| 6XYY | Update of ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE… | x-ray diffraction | A | NAG, MAN, 760, SO4 | 3 (best 0.76) |
| 6XYY | Update of ache from drosophila melanogaster complex with tacrine derivative… | x-ray diffraction | A | NAG, MAN, 760, SO4 | — |
| P07140 | AlphaFold monomer V2.0 prediction for acetylcholinesterase (P07140) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- MAN · alpha-D-mannopyranose · in 4 records
- 760 · 9-(3-phenylmethylamino)-1,2,3,4-tetrahydroacridine · in 2 records
- BMA · beta-D-mannopyranose · in 2 records
- CL · Chloride ion · in 2 records
- I40 · 9-(3-iodobenzylamino)-1,2,3,4-tetrahydroacridine · in 2 records
- IOD · Iodide ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6XYU chain A against the predicted model P07140: TM-score 1.00, RMSD 0.28 Å
- 6XYU chain A against the predicted model P07140: TM-score 1.00, RMSD 0.28 Å
- 6XYY chain A against the predicted model P07140: TM-score 1.00, RMSD 0.38 Å
- 6XYY chain A against the predicted model P07140: TM-score 1.00, RMSD 0.38 Å
- 6XYS chain A against the predicted model P07140: TM-score 1.00, RMSD 0.40 Å
- 6XYS chain A against the predicted model P07140: TM-score 1.00, RMSD 0.40 Å
- 1DX4 chain A against the predicted model P07140: TM-score 1.00, RMSD 0.45 Å
- 1QON chain A against the predicted model P07140: TM-score 1.00, RMSD 0.51 Å
- 1QO9 chain A against the predicted model P07140: TM-score 1.00, RMSD 0.58 Å
Elsewhere
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