UniProt P05165
Propionyl-CoA carboxylase alpha chain, mitochondrial (P05165)
Propionyl-CoA carboxylase alpha chain, mitochondrial (UniProt P05165), EC 6.4.1.3: 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 55 pockets. Binding sites, druggability and experiment against…
- UniProt
- P05165
- Protein
- Propionyl-CoA carboxylase alpha chain, mitochondrial
- EC
- 6.4.1.3
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 55 · 5 records with a druggable one
Structures
9 records of P05165 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CQY | Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit | solution nmr | A | — | — |
| 2CQY | Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit | solution nmr | A | — | — |
| 2JKU | Crystal structure of the N-terminal region of the biotin acceptor domain of human propionyl-CoA… | x-ray diffraction | A | — | — |
| 2JKU | Crystal structure of the N-terminal region of the biotin acceptor domain of human propionyl-CoA… | x-ray diffraction | A | — | — |
| 7YBU | Human propionyl-coenzyme A carboxylase | electron microscopy | A, B, D, F, H, J | BTI | 14 (best 0.81) |
| 8XL3 | Structure of human propionyl-CoA carboxylase at apo-state (PCC-Apo) | electron microscopy | A, C, E, G, I, K | BTN | 13 (best 0.80) |
| 8XL4 | Structure of human propionyl-CoA carboxylase in complex with acetyl-CoA (PCC-ACO) | electron microscopy | A, C, E, G, I, K | BTN | 12 (best 0.82) |
| 8XL5 | Structure of human propionyl-CoA carboxylase in complex with propionyl-CoA (PCC-PCO) | electron microscopy | A, C, E, G, I, K | BTN | 11 (best 0.83) |
| P05165 | AlphaFold monomer V2.0 prediction for propionyl-CoA carboxylase alpha chain, mitochondrial (P05165) | predicted | A | — | 5 (best 0.79) |
Ligands
Experiment against prediction
- 8XL4 chain G against the predicted model P05165: TM-score 0.97, RMSD 0.87 Å
- 2JKU chain A against the predicted model P05165: TM-score 0.91, RMSD 1.09 Å
- 2JKU chain A against the predicted model P05165: TM-score 0.91, RMSD 1.09 Å
- 8XL5 chain A against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
- 8XL5 chain I against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
- 8XL5 chain E against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
- 8XL5 chain K against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
- 8XL5 chain G against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
- 8XL5 chain C against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
- 8XL4 chain A against the predicted model P05165: TM-score 0.85, RMSD 3.48 Å
Elsewhere
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