UniProt P05102
Cytosine-specific methyltransferase hhai (P05102)
Cytosine-specific methyltransferase hhai (UniProt P05102), EC 2.1.1.73: 62 experimental structures on GenesisL1, 3 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P05102
- Protein
- Cytosine-specific methyltransferase hhai
- EC
- 2.1.1.73
- Experimental structures
- 62
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 16 · 3 records with a druggable one
Structures
62 records of P05102 in the MolNFT archive: 62 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 10MH | Ternary structure of hhai methyltransferase with adohcy and hemimethylated DNA containing… | x-ray diffraction | A | — | — |
| 10MH | Ternary structure of hhai methyltransferase with adohcy and hemimethylated DNA containing… | x-ray diffraction | A | — | — |
| 1FJX | Structure of ternary complex of hhai methyltransferase mutant (T250G) in complex with DNA and adohcy | x-ray diffraction | A | — | — |
| 1FJX | Structure of ternary complex of hhai methyltransferase mutant (T250G) in complex with DNA and adohcy | x-ray diffraction | A | — | — |
| 1HMY | Crystal structure of the hhai DNA methyltransferase complexed with S-adenosyl-L-methionine | x-ray diffraction | A | — | — |
| 1HMY | Crystal structure of the hhai DNA methyltransferase complexed with S- adenosyl-L-methionine | x-ray diffraction | A | — | — |
| 1M0E | Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA… | x-ray diffraction | A | — | — |
| 1M0E | Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA… | x-ray diffraction | A | — | — |
| 1MHT | Covalent ternary structure of hhai methyltransferase, DNA and S-adenosyl-L-homocysteine | x-ray diffraction | A | — | — |
| 1MHT | Covalent ternary structure of hhai methyltransferase, DNA and S- adenosyl-L-homocysteine | x-ray diffraction | A | — | — |
| 1SKM | HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its… | x-ray diffraction | A | — | — |
| 1SKM | Hhai methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its… | x-ray diffraction | A | — | — |
| 1SVU | Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein… | x-ray diffraction | A, B | — | — |
| 1SVU | Structure of the Q237W mutant of hhai DNA methyltransferase: an insight into protein-protein… | x-ray diffraction | A, B | — | — |
| 2C7O | HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to… | x-ray diffraction | A | — | — |
| 2C7O | Hhai DNA methyltransferase complex with 13MER oligonucleotide containing 2-aminopurine adjacent to… | x-ray diffraction | A | — | — |
| 2C7P | HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the… | x-ray diffraction | A | — | — |
| 2C7P | Hhai DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the… | x-ray diffraction | A | — | — |
| 2C7Q | HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the… | x-ray diffraction | A | — | — |
| 2C7Q | Hhai DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the… | x-ray diffraction | A | — | — |
| 2C7R | HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as… | x-ray diffraction | A | — | — |
| 2C7R | Hhai DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as… | x-ray diffraction | A | — | — |
| 2HMY | Binary complex of hhai methyltransferase with adomet formed in the presence of a short nonpsecific… | x-ray diffraction | B | — | — |
| 2HMY | Binary complex of hhai methyltransferase with adomet formed in the presence of a short nonpsecific… | x-ray diffraction | B | — | — |
| 2HR1 | Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy | x-ray diffraction | A | — | — |
| 2HR1 | Ternary structure of wt M.HHAI C5-cytosine DNA methyltransferase with unmodified DNA and adohcy | x-ray diffraction | A | — | — |
| 2I9K | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA… | x-ray diffraction | A | — | — |
| 2I9K | Engineered extrahelical base destabilization enhances sequence discrimination of DNA… | x-ray diffraction | A | — | — |
| 2UYC | HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH | x-ray diffraction | A | — | — |
| 2UYC | Hhai DNA methyltransferase R163N mutant complex with 13MER gcgc-gmgc oligonucleotide and sah | x-ray diffraction | A | — | — |
| 2UYH | HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH | x-ray diffraction | A | — | — |
| 2UYH | Hhai DNA methyltransferase S87Q-Q237S mutant complex with 13MER gcgc- gmgc oligonucleotide and sah | x-ray diffraction | A | — | — |
| 2UZ4 | HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH | x-ray diffraction | A | — | — |
| 2UZ4 | Hhai DNA methyltransferase R165N mutant complex with 13MER gcgc-gmgc oligonucleotide and sah | x-ray diffraction | A | — | — |
| 2Z6A | S-Adenosyl-L-methionine-Dependent Methyl Transfer: Observable Precatalytic Intermediates during DNA… | x-ray diffraction | A | — | — |
| 2Z6A | S-adenosyl-L-methionine-dependent methyl transfer: observable precatalytic intermediates during DNA… | x-ray diffraction | A | — | — |
| 2Z6Q | Ternary structure of Arg165Ala M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and… | x-ray diffraction | A | — | — |
| 2Z6Q | Ternary structure of ARG165ALA M.HHAI C5-cytosine DNA methyltransferase with unmodified DNA and… | x-ray diffraction | A | — | — |
| 2Z6U | Ternary structure of the Glu119Ala M.HhaI, C5-Cytosine DNA methyltransferase, with unmodified DNA… | x-ray diffraction | A | — | — |
| 2Z6U | Ternary structure of the GLU119ALA M.HHAI, C5-cytosine DNA methyltransferase, with unmodified DNA… | x-ray diffraction | A | — | — |
| 2ZCJ | Ternary structure of the Glu119Gln M.HhaI, C5-Cytosine DNA methyltransferase, with unmodified DNA… | x-ray diffraction | A | — | — |
| 2ZCJ | Ternary structure of the GLU119GLN M.HHAI, C5-cytosine DNA methyltransferase, with unmodified DNA… | x-ray diffraction | A | — | — |
| 3EEO | M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the… | x-ray diffraction | A | — | — |
| 3EEO | M. hhai co-crystallized with synthetic dsdna containing a propane diol in place of the… | x-ray diffraction | A | — | — |
| 3MHT | Ternary structure of hhai methyltransferase with unmodified DNA and adohcy | x-ray diffraction | A | — | — |
| 3MHT | Ternary structure of hhai methyltransferase with unmodified DNA and adohcy | x-ray diffraction | A | — | — |
| 4MHT | Ternary structure of hhai methyltransferase with native DNA and adohcy | x-ray diffraction | A | — | — |
| 4MHT | Ternary structure of hhai methyltransferase with native DNA and adohcy | x-ray diffraction | A | — | — |
| 5CIY | Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain | x-ray diffraction | A | SO4 | — |
| 5CIY | Structural basis of the recognition of H3K36ME3 by DNMT3B pwwp domain | x-ray diffraction | A | — | — |
| 5LOD | Crystal structure of HhaI DNA methyltransferase in APO form | x-ray diffraction | B, A | SO4 | — |
| 5LOD | Crystal structure of hhai DNA methyltransferase in apo form | x-ray diffraction | B, A | SO4 | — |
| 5MHT | Ternary structure of hhai methyltransferase with hemimethylated DNA and adohcy | x-ray diffraction | A | — | — |
| 5MHT | Ternary structure of hhai methyltransferase with hemimethylated DNA and adohcy | x-ray diffraction | A | — | — |
| 6MHT | Ternary structure of hhai methyltransferase with adohcy and DNA containing 4'-thio-2'DEOXYCYTIDINE… | x-ray diffraction | A | SAM | 6 (best 0.74) |
| 6MHT | Ternary structure of hhai methyltransferase with adohcy and DNA containing 4'-thio-2'DEOXYCYTIDINE… | x-ray diffraction | A | SAM | — |
| 7MHT | Cytosine-specific methyltransferase HHAI/DNA complex | x-ray diffraction | A | — | — |
| 8MHT | Cytosine-specific methyltransferase HHAI/DNA complex | x-ray diffraction | A | SAH | 5 (best 0.74) |
| 8MHT | Cytosine-specific methyltransferase HHAI/DNA complex | x-ray diffraction | A | — | — |
| 9MHT | Cytosine-specific methyltransferase HHAI/DNA complex | x-ray diffraction | A | SAH | 5 (best 0.76) |
2 records more on the page itself.
Ligands
Elsewhere
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