UniProt P04844
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (P04844)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (UniProt P04844): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 18 pockets. Binding sites, druggability and experiment…
- UniProt
- P04844
- Protein
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 18 · 5 records with a druggable one
Structures
7 records of P04844 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6S7O | Cryo-EM structure of human oligosaccharyltransferase complex OST-A | electron microscopy | F | MAN, EGY, KZB | 6 (best 0.73) |
| 6S7O | Cryo-EM structure of human oligosaccharyltransferase complex ost-a | electron microscopy | F | MAN, EGY, KZB | — |
| 6S7T | Cryo-EM structure of human oligosaccharyltransferase complex OST-B | electron microscopy | F | MAN, EGY, KZB | 3 (best 0.73) |
| 6S7T | Cryo-EM structure of human oligosaccharyltransferase complex ost-B | electron microscopy | F | MAN, EGY, KZB | — |
| 8B6L | Subtomogram average of the human Sec61-TRAP-OSTA-translocon | electron microscopy | P | — | 3 (best 0.75) |
| 8PN9 | Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1 | electron microscopy | F | MAN, KZB, EGY | 4 (best 0.78) |
| P04844 | AlphaFold monomer V2.0 prediction for dolichyl- diphosphooligosaccharide--protein… | predicted | A | — | 2 (best 0.53) |
Ligands
- EGY · (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium · in 5 records
- KZB · (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S}, 9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13, 18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol · in 5 records
- MAN · alpha-D-mannopyranose · in 5 records
Experiment against prediction
- 8B6L chain P against the predicted model P04844: TM-score 0.83, RMSD 2.06 Å
- 6S7T chain F against the predicted model P04844: TM-score 0.59, RMSD 3.28 Å
- 6S7T chain F against the predicted model P04844: TM-score 0.59, RMSD 3.28 Å
- 8PN9 chain F against the predicted model P04844: TM-score 0.57, RMSD 3.12 Å
- 6S7O chain F against the predicted model P04844: TM-score 0.56, RMSD 3.16 Å
- 6S7O chain F against the predicted model P04844: TM-score 0.56, RMSD 3.16 Å
Elsewhere
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