UniProt P04183
Thymidine kinase, cytosolic (P04183)
Thymidine kinase, cytosolic (UniProt P04183): 8 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04183
- Protein
- Thymidine kinase, cytosolic
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
9 records of P04183 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W4R | Structure of a type II thymidine kinase with bound dTTP | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1W4R | Structure of a type II thymidine kinase with bound dttp | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1XBT | Crystal Structure of Human Thymidine Kinase 1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1XBT | Crystal structure of human thymidine kinase 1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2ORV | human Thymidine Kinase 1 in complex with TP4A | x-ray diffraction | A, B | — | — |
| 2ORV | Human thymidine kinase 1 in complex with TP4A | x-ray diffraction | A, B | — | — |
| 2WVJ | Mutation of Thr163 to Ser in Human Thymidine Kinase Shifts the Specificity from Thymidine towards… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WVJ | Mutation of THR163 to ser in human thymidine kinase shifts the specificity from thymidine towards… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| P04183 | AlphaFold monomer V2.0 prediction for thymidine kinase, cytosolic (P04183) | predicted | A | — | 2 (best 0.64) |
Experiment against prediction
- 1XBT chain A against the predicted model P04183: TM-score 1.00, RMSD 0.25 Å
- 1XBT chain A against the predicted model P04183: TM-score 1.00, RMSD 0.25 Å
- 1W4R chain C against the predicted model P04183: TM-score 1.00, RMSD 0.25 Å
- 1W4R chain C against the predicted model P04183: TM-score 1.00, RMSD 0.25 Å
- 1XBT chain F against the predicted model P04183: TM-score 1.00, RMSD 0.28 Å
- 1XBT chain F against the predicted model P04183: TM-score 1.00, RMSD 0.28 Å
- 2WVJ chain A against the predicted model P04183: TM-score 1.00, RMSD 0.28 Å
- 2WVJ chain A against the predicted model P04183: TM-score 1.00, RMSD 0.28 Å
- 1XBT chain H against the predicted model P04183: TM-score 1.00, RMSD 0.29 Å
- 1XBT chain H against the predicted model P04183: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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