UniProt P04036
Dihydrodipicolinate reductase (P04036)
Dihydrodipicolinate reductase (UniProt P04036), EC 1.3.1.26: 10 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P04036
- Protein
- Dihydrodipicolinate reductase
- EC
- 1.3.1.26
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 21 · 4 records with a druggable one
Structures
11 records of P04036 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ARZ | Escherichia COLI dihydrodipicolinate reductase in complex with NADH and 2,6 pyridine dicarboxylate | x-ray diffraction | A, B, C, D | PO4, K, NAI, PDC | 13 (best 0.87) |
| 1ARZ | Escherichia COLI dihydrodipicolinate reductase in complex with NADH and 2,6 pyridine dicarboxylate | x-ray diffraction | A, B, C, D | — | — |
| 1DIH | Three-dimensional structure of E. COLI dihydrodipicolinate reductase | x-ray diffraction | A | NDP | 2 (best 0.54) |
| 1DIH | Three-dimensional structure of E. COLI dihydrodipicolinate reductase | x-ray diffraction | A | — | — |
| 1DRU | Escherichia COLI DHPR/NADH complex | x-ray diffraction | A | NAD | 2 (best 0.66) |
| 1DRU | Escherichia COLI DHPR/NADH complex | x-ray diffraction | A | — | — |
| 1DRV | Escherichia COLI DHPR/ACNADH complex | x-ray diffraction | A | A3D | 1 (best 0.66) |
| 1DRV | Escherichia COLI DHPR/ACNADH complex | x-ray diffraction | A | — | — |
| 1DRW | Escherichia COLI DHPR/NHDH complex | x-ray diffraction | A | NHD | 3 (best 0.49) |
| 1DRW | Escherichia COLI DHPR/NHDH complex | x-ray diffraction | A | — | — |
| P04036 | AlphaFold monomer V2.0 prediction for 4-hydroxy- tetrahydrodipicolinate reductase (P04036) | predicted | A | — | — |
Ligands
- A3D · 3-acetylpyridine adenine dinucleotide · in 1 record
- K · Potassium ion · in 1 record
- NAD · Nicotinamide-adenine-dinucleotide · in 1 record
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 1 record
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 1 record
- NHD · Nicotinamide purin-6-ol-dinucleotide · in 1 record
- PDC · Pyridine-2,6-dicarboxylic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 1DRU chain A against the predicted model P04036: TM-score 0.98, RMSD 0.93 Å
- 1DRU chain A against the predicted model P04036: TM-score 0.98, RMSD 0.93 Å
- 1DRV chain A against the predicted model P04036: TM-score 0.98, RMSD 0.89 Å
- 1DRV chain A against the predicted model P04036: TM-score 0.98, RMSD 0.89 Å
- 1ARZ chain A against the predicted model P04036: TM-score 0.96, RMSD 1.33 Å
- 1ARZ chain A against the predicted model P04036: TM-score 0.96, RMSD 1.33 Å
- 1DRW chain A against the predicted model P04036: TM-score 0.92, RMSD 1.95 Å
- 1DRW chain A against the predicted model P04036: TM-score 0.92, RMSD 1.95 Å
- 1DIH chain A against the predicted model P04036: TM-score 0.91, RMSD 1.99 Å
- 1DIH chain A against the predicted model P04036: TM-score 0.91, RMSD 1.99 Å
Elsewhere
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