UniProt P03959
Potassium-transporting ATPase potassium-binding subunit (P03959)
Potassium-transporting ATPase potassium-binding subunit (UniProt P03959): 25 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 166 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P03959
- Protein
- Potassium-transporting ATPase potassium-binding subunit
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 166 · 15 records with a druggable one
Structures
26 records of P03959 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MRW | Structure of the KdpFABC complex | x-ray diffraction | A, E, I | K, PX4 | — |
| 5MRW | Structure of the kdpfabc complex | x-ray diffraction | A, E, I | K, PX4 | — |
| 6HRA | Cryo-EM structure of the KdpFABC complex in an E1 outward-facing state (state 1) | electron microscopy | A | K | — |
| 6HRA | Cryo-EM structure of the kdpfabc complex in an E1 outward-facing state (state 1) | electron microscopy | A | K | — |
| 6HRB | Cryo-EM structure of the KdpFABC complex in an E2 inward-facing state (state 2) | electron microscopy | A | K | — |
| 6HRB | Cryo-EM structure of the kdpfabc complex in an E2 inward-facing state (state 2) | electron microscopy | A | K | — |
| 7BGY | Cryo-EM Structure of KdpFABC in E2Pi state with MgF4 | electron microscopy | A | PEV, 9Y0 | 12 (best 0.77) |
| 7BGY | Cryo-EM structure of kdpfabc in E2PI state with MGF4 | electron microscopy | A | PEV, 9Y0 | — |
| 7BH1 | Cryo-EM Structure of KdpFABC in E1 state with K | electron microscopy | A | K, 9Y0 | 12 (best 0.73) |
| 7BH1 | Cryo-EM structure of kdpfabc in E1 state with K | electron microscopy | A | K, 9Y0 | — |
| 7BH2 | Cryo-EM Structure of KdpFABC in E2Pi state with BeF3 and K+ | electron microscopy | A | K, 9Y0 | 11 (best 0.79) |
| 7BH2 | Cryo-EM structure of kdpfabc in E2PI state with BEF3 and K+ | electron microscopy | A | K, 9Y0 | — |
| 7LC3 | CryoEM Structure of KdpFABC in E1-ATP state | electron microscopy | A | K, 9Y0 | 12 (best 0.78) |
| 7LC3 | Cryoem structure of kdpfabc in E1-ATP state | electron microscopy | A | K, 9Y0 | — |
| 7LC6 | Cryo-EM Structure of KdpFABC in E2-P state with BeF3 | electron microscopy | A | K, 9Y0 | 11 (best 0.81) |
| 7LC6 | Cryo-EM structure of kdpfabc in E2-P state with BEF3 | electron microscopy | A | K, 9Y0 | — |
| 7ZRD | Cryo-EM map of the WT KdpFABC complex in the E1-P tight conformation, stabilised with the inhibitor… | electron microscopy | A | K, CDL | 11 (best 0.78) |
| 7ZRE | Cryo-EM map of the WT KdpFABC complex in the E1-P tight conformation, under turnover conditions | electron microscopy | A | K, CDL | 10 (best 0.79) |
| 7ZRG | Cryo-EM map of the WT KdpFABC complex in the E1_ATPearly conformation, under turnover conditions | electron microscopy | A | K, CDL | 11 (best 0.78) |
| 7ZRH | Cryo-EM structure of the KdpFABC complex in a nucleotide-free E1 conformation loaded with K+ | electron microscopy | A | K, CDL | 10 (best 0.79) |
| 7ZRI | Cryo-EM structure of the KdpFABC complex in a nucleotide-free E1 conformation loaded with K+ | electron microscopy | A | K, CDL | 11 (best 0.81) |
| 7ZRJ | Cryo-EM structure of the KdpFABC complex in a nucleotide-free E1 conformation loaded with K+ | electron microscopy | A | K, CDL | 10 (best 0.80) |
| 7ZRK | Cryo-EM map of the WT KdpFABC complex in the E1-P_ADP conformation, under turnover conditions | electron microscopy | A | K, CDL | 13 (best 0.78) |
| 7ZRL | Cryo-EM map of the unphosphorylated KdpFABC complex in the E2-P conformation, under turnover… | electron microscopy | A | K | 13 (best 0.73) |
| 7ZRM | Cryo-EM map of the unphosphorylated KdpFABC complex in the E1-P_ADP conformation, under turnover… | electron microscopy | A | K | 13 (best 0.81) |
| P03959 | AlphaFold monomer V2.0 prediction for potassium-transporting ATPase potassium-binding subunit… | predicted | A | — | 6 (best 0.71) |
Ligands
- K · Potassium ion · in 23 records
- 9Y0 · (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate · in 10 records
- CDL · Cardiolipin · in 7 records
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 2 records
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 2 records
Experiment against prediction
- 7LC3 chain A against the predicted model P03959: TM-score 1.00, RMSD 0.36 Å
- 7LC3 chain A against the predicted model P03959: TM-score 1.00, RMSD 0.36 Å
- 5MRW chain A against the predicted model P03959: TM-score 1.00, RMSD 0.40 Å
- 5MRW chain A against the predicted model P03959: TM-score 1.00, RMSD 0.40 Å
- 7BGY chain A against the predicted model P03959: TM-score 1.00, RMSD 0.41 Å
- 7BGY chain A against the predicted model P03959: TM-score 1.00, RMSD 0.41 Å
- 7ZRK chain A against the predicted model P03959: TM-score 1.00, RMSD 0.42 Å
- 7ZRE chain A against the predicted model P03959: TM-score 1.00, RMSD 0.46 Å
- 7ZRG chain A against the predicted model P03959: TM-score 1.00, RMSD 0.47 Å
- 7ZRD chain A against the predicted model P03959: TM-score 1.00, RMSD 0.47 Å
Elsewhere
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