UniProt P03952
Plasma kallikrein (P03952)
Plasma kallikrein (UniProt P03952), EC 3.4.21.34: 28 experimental structures on GenesisL1, 12 ligands bound, 30 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03952
- Protein
- Plasma kallikrein
- EC
- 3.4.21.34
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 30 · 4 records with a druggable one
Structures
28 records of P03952 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ANW | Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma… | x-ray diffraction | A | — | — |
| 2ANW | Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma… | x-ray diffraction | A | — | — |
| 2ANY | Expression, Crystallization and the Three-dimensional Structure of the Catalytic Domain of Human… | x-ray diffraction | A | — | — |
| 2ANY | Expression, crystallization and the three-dimensional structure of the catalytic domain of human… | x-ray diffraction | A | — | — |
| 4OGX | Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution | x-ray diffraction | A | — | — |
| 4OGX | Crystal structure of Fab dx-2930 in complex with human plasma kallikrein at 2.4 ångström resolution | x-ray diffraction | A | — | — |
| 4OGY | Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 4OGY | Crystal structure of Fab dx-2930 in complex with human plasma kallikrein at 2.1 ångström resolution | x-ray diffraction | A, B | — | — |
| 5F8T | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2 | x-ray diffraction | A | — | — |
| 5F8T | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2 | x-ray diffraction | A | SO4, MRZ | 2 (best 0.45) |
| 5F8T | The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-2 | x-ray diffraction | A | — | — |
| 5F8X | The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-3 | x-ray diffraction | A | SO4, MRZ | — |
| 5F8X | The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-3 | x-ray diffraction | A | — | — |
| 5F8Z | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1 | x-ray diffraction | A | SO4, MRZ | — |
| 5F8Z | The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-1 | x-ray diffraction | A | — | — |
| 5TJX | Structure of human plasma kallikrein | x-ray diffraction | A | GBT, PO4 | 4 (best 0.48) |
| 5TJX | Structure of human plasma kallikrein | x-ray diffraction | A | GBT, PO4 | — |
| 6I44 | Allosteric activation of human prekallikrein by apple domain disc rotation | x-ray diffraction | A | NAG, BEN, SO4, NA | — |
| 6O1G | Full length human plasma kallikrein with inhibitor | x-ray diffraction | A | NAG, 7SD | 8 (best 0.82) |
| 6O1G | Full length human plasma kallikrein with inhibitor | x-ray diffraction | A | NAG, 7SD | — |
| 6O1S | Structure of human plasma kallikrein protease domain with inhibitor | x-ray diffraction | E | PO4, 7SD | 2 (best 0.55) |
| 6O1S | Structure of human plasma kallikrein protease domain with inhibitor | x-ray diffraction | E | PO4, 7SD | — |
| 6T7P | human plasmakallikrein protease domain in complex with active site directed inhibitor | x-ray diffraction | A | GSH, PO4, MU8 | 3 (best 0.46) |
| 6T7P | Human plasmakallikrein protease domain in complex with active site directed inhibitor | x-ray diffraction | A | GSH, PO4, MU8 | — |
| 7N7X | Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease… | x-ray diffraction | AAA | 0RI, PO4 | 3 (best 0.42) |
| 7QOX | Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes | x-ray diffraction | A, B | NAG | 6 (best 0.83) |
| 8A3Q | Human Plasma Kallekrein in complex with 14W | x-ray diffraction | A | UNL, NAG | 2 (best 0.59) |
| P03952 | AlphaFold monomer V2.0 prediction for plasma kallikrein (P03952) | — | — | — |
Ligands
- PO4 · Phosphate ion · in 7 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- 7SD · N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]-1-({4-[(1H-pyrazol-1-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide · in 4 records
- SO4 · Sulfate ion · in 4 records
- MRZ · piperidine-1-carboximidamide · in 3 records
- GBT · (8E)-3-amino-1-methyl-15-[(1H-pyrazol-1-yl)methyl]-7, 10,11,12,24,25-hexahydro-6H,18H,23H-19,22-(metheno) pyrido[4,3-J][1,9,13,17, 18]benzodioxatriazacyclohenicosin-23-one · in 2 records
- GSH · Glutathione · in 2 records
- MU8 · (2~{S},4~{R})-1-[[(3~{S})-3-azanyl-2,3-dihydro-1-benzofuran-6-yl]carbonyl]-~{N}-(3-chlorophenyl)-4-phenyl-pyrrolidine-2-carboxamide · in 2 records
- 0RI · Orladeyo · in 1 record
- BEN · Benzamidine · in 1 record
- NA · Sodium ion · in 1 record
- UNL · Unknown ligand · in 1 record
Elsewhere
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