UniProt P02748
Complement component C9 (P02748)
Complement component C9 (UniProt P02748): 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02748
- Protein
- Complement component C9
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 32 · 3 records with a druggable one
Structures
12 records of P02748 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FMW | The poly-C9 component of the Complement Membrane Attack Complex | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | — |
| 5FMW | The poly-C9 component of the complement membrane attack complex | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | — |
| 6DLW | Complement component polyC9 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | NAG, BMA | — |
| 6DLW | Complement component POLYC9 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | NAG, BMA | — |
| 6H03 | Open conformation of the membrane attack complex | electron microscopy | G, P, H, I, J, K, L, M, N, O, Q, R, S, T, U, V, W, X | NAG | — |
| 6H04 | Closed conformation of the Membrane Attack Complex | electron microscopy | L, M, N, O, Q, R, S, T, U, V, W, X, P, H, I, J, K, G | NAG | — |
| 6H04 | Closed conformation of the membrane attack complex | electron microscopy | L, M, N, O, Q, R, S, T, U, V, W, X, P, H, I, J, K, G | NAG | — |
| 7NYC | Cryoem structure of 3C9-smac | electron microscopy | G, H, I | BMA, NAG, CA | — |
| 8B0G | 2C9, C5b9-CD59 structure | electron microscopy | H, J, I | NAG | 7 (best 0.87) |
| 8B0H | 2C9, C5b9-CD59 cryoEM structure | electron microscopy | H, I | — | 5 (best 0.85) |
| 8DE6 | Oligomeric C9 in complex with aE11 Fab | electron microscopy | A, C, G | NAG, BMA, CA | 20 (best 0.86) |
| P02748 | AlphaFold monomer V2.0 prediction for complement component C9 (P02748) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8B0G chain J against the predicted model P02748: TM-score 0.88, RMSD 2.91 Å
- 8B0H chain I against the predicted model P02748: TM-score 0.87, RMSD 3.13 Å
- 7NYC chain I against the predicted model P02748: TM-score 0.86, RMSD 2.68 Å
- 8B0G chain I against the predicted model P02748: TM-score 0.84, RMSD 2.96 Å
- 7NYC chain G against the predicted model P02748: TM-score 0.84, RMSD 3.13 Å
- 8DE6 chain A against the predicted model P02748: TM-score 0.83, RMSD 3.14 Å
- 8DE6 chain C against the predicted model P02748: TM-score 0.82, RMSD 3.16 Å
- 8B0H chain H against the predicted model P02748: TM-score 0.82, RMSD 3.00 Å
- 8DE6 chain G against the predicted model P02748: TM-score 0.82, RMSD 3.15 Å
- 8B0G chain H against the predicted model P02748: TM-score 0.82, RMSD 3.02 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.