UniProt P02712
Acetylcholine receptor subunit beta (P02712)
Acetylcholine receptor subunit beta (UniProt P02712): 16 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 58 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02712
- Protein
- Acetylcholine receptor subunit beta
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 58 · 7 records with a druggable one
Structures
17 records of P02712 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UWZ | Cryo-EM structure of torpedo acetylcholine receptor in complex with alpha-bungarotoxin | electron microscopy | C | NAG, POV | — |
| 7QKO | Torpedo muscle-type nicotinic acetylcholine receptor - resting conformation | electron microscopy | B | NAG, MAN, POV | — |
| 7QL5 | Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | electron microscopy | B | NAG, BMA, POV | — |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | B | NAG, MAN | 9 (best 0.83) |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | B | NAG, MAN | — |
| 7SMM | Cryo-EM structure of torpedo acetylcholine receptor in apo form | electron microscopy | C | NAG, POV, CLR | — |
| 7SMQ | Cryo-EM structure of torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | C | NAG, POV, CLR | — |
| 7SMR | Cryo-EM structure of Torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | C | NAG, BMA, POV, CLR | 9 (best 0.84) |
| 7SMR | Cryo-EM structure of torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | C | NAG, BMA, POV, CLR | — |
| 7SMS | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine | electron microscopy | C | NAG, BMA, TC9, POV, CLR | 8 (best 0.83) |
| 7SMS | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine | electron microscopy | C | NAG, BMA, TC9, POV, CLR | — |
| 7SMT | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine and carbachol | electron microscopy | C | NAG, BMA, POV, CLR | — |
| 7Z14 | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | B | NAG | 8 (best 0.72) |
| 7Z14 | Cryo-EM structure of torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | B | NAG | 8 (best 0.72) |
| 8F6Y | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate… | electron microscopy | C | NAG, BMA, POV, CLR | 9 (best 0.82) |
| 8F6Z | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine… | electron microscopy | C | NAG, POV, CLR | 7 (best 0.84) |
| P02712 | AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit beta (P02712) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 16 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 12 records
- CLR · Cholesterol · in 9 records
- BMA · beta-D-mannopyranose · in 7 records
- MAN · alpha-D-mannopyranose · in 3 records
- TC9 · D-tubocurarine · in 2 records
Experiment against prediction
- 7Z14 chain B against the predicted model P02712: TM-score 0.99, RMSD 0.61 Å
- 7Z14 chain B against the predicted model P02712: TM-score 0.99, RMSD 0.61 Å
- 7SMQ chain C against the predicted model P02712: TM-score 0.99, RMSD 0.69 Å
- 6UWZ chain C against the predicted model P02712: TM-score 0.99, RMSD 0.70 Å
- 7SMM chain C against the predicted model P02712: TM-score 0.99, RMSD 0.70 Å
- 7QKO chain B against the predicted model P02712: TM-score 0.99, RMSD 0.75 Å
- 7SMT chain C against the predicted model P02712: TM-score 0.99, RMSD 0.77 Å
- 7QL5 chain B against the predicted model P02712: TM-score 0.99, RMSD 0.81 Å
- 7SMR chain C against the predicted model P02712: TM-score 0.99, RMSD 0.80 Å
- 7SMR chain C against the predicted model P02712: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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