UniProt P00803
Signal peptidase I (P00803)
Signal peptidase I (UniProt P00803), EC 3.4.21.89: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00803
- Protein
- Signal peptidase I
- EC
- 3.4.21.89
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 29 · 3 records with a druggable one
Structures
13 records of P00803 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B12 | Crystal structure of type 1 signal peptidase from escherichia COLI in complex with a beta-lactam… | x-ray diffraction | A, B, C, D | 1PN, PO4 | 13 (best 0.65) |
| 1B12 | Crystal structure of type 1 signal peptidase from escherichia COLI in complex with a beta-lactam… | x-ray diffraction | A, B, C, D | — | — |
| 1KN9 | Crystal structure of a bacterial signal peptidase apo-enzyme, implications for signal peptide… | x-ray diffraction | A, B, C, D | — | 8 (best 0.69) |
| 1KN9 | Crystal structure of a bacterial signal peptidase apo-enzyme, implications for signal peptide… | x-ray diffraction | A, B, C, D | — | — |
| 1T7D | Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide… | x-ray diffraction | A, B | M12 | 1 (best 0.47) |
| 1T7D | Crystal structure of escherichia COLI type I signal peptidase in complex with a lipopeptide… | x-ray diffraction | A, B | — | — |
| 3IIQ | Crystallographic analysis of bacterial signal peptidase in ternary complex with Arylomycin A2 and a… | x-ray diffraction | A, B | — | — |
| 3IIQ | Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a… | x-ray diffraction | A, B | — | — |
| 3S04 | Crystal structure of Escherichia coli type I signal peptidase in complex with an Arylomycin… | x-ray diffraction | A, B | — | — |
| 3S04 | Crystal structure of escherichia COLI type I signal peptidase in complex with an arylomycin… | x-ray diffraction | A, B | — | — |
| 6B88 | E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-meth… | x-ray diffraction | A, B | CZD | 4 (best 0.47) |
| 6B88 | E. COLI lepb in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2… | x-ray diffraction | A, B | CZD | — |
| P00803 | AlphaFold monomer V2.0 prediction for signal peptidase I (P00803) | predicted | A | — | 3 (best 0.65) |
Ligands
- CZD · (8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19), 2(20),3,5,15,17-hexaene-8-carboxamide · in 2 records
- 1PN · prop-2-en-1-yl (2S)-2-[(2S,3R)-3-(acetyloxy)-1-oxobutan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylate · in 1 record
- M12 · 10-methylundecanoic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 3IIQ chain A against the predicted model P00803: TM-score 0.99, RMSD 0.67 Å
- 3IIQ chain A against the predicted model P00803: TM-score 0.99, RMSD 0.67 Å
- 1T7D chain B against the predicted model P00803: TM-score 0.98, RMSD 0.80 Å
- 1T7D chain B against the predicted model P00803: TM-score 0.98, RMSD 0.80 Å
- 1T7D chain A against the predicted model P00803: TM-score 0.98, RMSD 0.80 Å
- 1T7D chain A against the predicted model P00803: TM-score 0.98, RMSD 0.80 Å
- 3S04 chain A against the predicted model P00803: TM-score 0.98, RMSD 0.88 Å
- 3S04 chain A against the predicted model P00803: TM-score 0.98, RMSD 0.88 Å
- 3IIQ chain B against the predicted model P00803: TM-score 0.97, RMSD 1.04 Å
- 3IIQ chain B against the predicted model P00803: TM-score 0.97, RMSD 1.04 Å
Elsewhere
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