UniProt P00740
Coagulation factor IX (P00740)
Coagulation factor IX (UniProt P00740), EC 3.4.21.22: 92 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00740
- Protein
- Coagulation factor IX
- EC
- 3.4.21.22
- Experimental structures
- 92
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 47 · 9 records with a druggable one
Structures
93 records of P00740 in the MolNFT archive: 92 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CFH | Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by… | solution nmr | A | — | — |
| 1CFH | Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by… | solution nmr | A | — | — |
| 1CFI | NMR structure of calcium ion-bound gamma-carboxy-glutamic acid-rich domain of factor IX | solution nmr | A | — | — |
| 1CFI | NMR structure of calcium ion-bound gamma-carboxy-glutamic acid-rich domain of factor IX | solution nmr | A | — | — |
| 1EDM | Epidermal growth factor-like domain from human factor IX | x-ray diffraction | B, C | — | — |
| 1EDM | Epidermal growth factor-like domain from human factor IX | x-ray diffraction | B, C | — | — |
| 1IXA | The three-dimensional structure of the first EGF-like module of human factor IX: comparison with… | solution nmr | A | — | — |
| 1IXA | The three-dimensional structure of the first EGF-like module of human factor IX: comparison with… | solution nmr | A | — | — |
| 1MGX | Coagulation factor, MG(II), NMR, 7 structures (backbone atoms only) | solution nmr | A | — | — |
| 1MGX | Coagulation factor, MG(II), NMR, 7 structures (backbone atoms only) | solution nmr | A | — | — |
| 1NL0 | Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12 | x-ray diffraction | G | — | — |
| 1NL0 | Crystal structure of human factor IX gla domain in complex of an inhibitory antibody, 10C12 | x-ray diffraction | G | — | — |
| 1RFN | Human coagulation factor ixa in complex with P-amino benzamidine | x-ray diffraction | A, B | — | — |
| 1RFN | Human coagulation factor ixa in complex with P-amino benzamidine | x-ray diffraction | A, B | — | — |
| 2WPH | factor IXa superactive triple mutant | x-ray diffraction | E, S | — | — |
| 2WPH | Factor ixa superactive triple mutant | x-ray diffraction | E, S | — | — |
| 2WPI | factor IXa superactive double mutant | x-ray diffraction | E, S | — | — |
| 2WPI | Factor ixa superactive double mutant | x-ray diffraction | E, S | — | — |
| 2WPJ | factor IXa superactive triple mutant, NaCl-soaked | x-ray diffraction | E, S | — | — |
| 2WPJ | Factor ixa superactive triple mutant, nacl-soaked | x-ray diffraction | E, S | — | — |
| 2WPK | factor IXa superactive triple mutant, ethylene glycol-soaked | x-ray diffraction | E, S | — | — |
| 2WPK | Factor ixa superactive triple mutant, ethylene glycol-soaked | x-ray diffraction | E, S | — | — |
| 2WPL | factor IXa superactive triple mutant, EDTA-soaked | x-ray diffraction | E, S | — | — |
| 2WPL | Factor ixa superactive triple mutant, edta-soaked | x-ray diffraction | E, S | — | — |
| 2WPM | factor IXa superactive mutant, EGR-CMK inhibited | x-ray diffraction | E, S | — | — |
| 2WPM | Factor ixa superactive mutant, egr-cmk inhibited | x-ray diffraction | E, S | — | — |
| 3KCG | Crystal structure of the antithrombin-factor IXa-pentasaccharide complex | x-ray diffraction | L, H | — | — |
| 3KCG | Crystal structure of the antithrombin-factor ixa-pentasaccharide complex | x-ray diffraction | L, H | — | — |
| 3LC3 | Benzothiophene Inhibitors of Factor IXa | x-ray diffraction | A, B, C, D | — | — |
| 3LC3 | Benzothiophene inhibitors of factor ixa | x-ray diffraction | A, B, C, D | — | — |
| 3LC5 | Selective Benzothiophine Inhibitors of Factor IXa | x-ray diffraction | A, B | — | — |
| 3LC5 | Selective benzothiophine inhibitors of factor ixa | x-ray diffraction | A, B | — | — |
| 4WM0 | Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with acceptor ligand | x-ray diffraction | D | — | — |
| 4WM0 | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with acceptor ligand | x-ray diffraction | D | — | — |
| 4WMA | Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese,acceptor ligand… | x-ray diffraction | D | — | — |
| 4WMA | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with MANGANESE,ACCEPTOR ligand… | x-ray diffraction | D | — | — |
| 4WMB | crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese, acceptor ligand… | x-ray diffraction | D | — | — |
| 4WMB | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with manganese, acceptor ligand… | x-ray diffraction | D | — | — |
| 4WMI | Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese, product ligand… | x-ray diffraction | D | — | — |
| 4WMI | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with manganese, product ligand… | x-ray diffraction | D | — | — |
| 4WMK | Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese, product ligand… | x-ray diffraction | D | — | — |
| 4WMK | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with manganese, product ligand… | x-ray diffraction | D | — | — |
| 4WN2 | Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese, product ligand… | x-ray diffraction | D | — | — |
| 4WN2 | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with manganese, product ligand… | x-ray diffraction | D | — | — |
| 4WNH | Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese,acceptor ligand… | x-ray diffraction | D | — | — |
| 4WNH | Crystal structure of mouse xyloside xylosyltransferase 1 complexed with MANGANESE,ACCEPTOR ligand… | x-ray diffraction | D | — | — |
| 4YZU | Rapid development of two Factor IXa inhibitors from Hit to Lead | x-ray diffraction | A, B | — | — |
| 4YZU | Rapid development of two factor ixa inhibitors from hit to lead | x-ray diffraction | A, B | — | — |
| 4Z0K | Rapid development of two Factor IXa inhibitors from Hit to Lead | x-ray diffraction | A, B | — | — |
| 4Z0K | Rapid development of two factor ixa inhibitors from hit to lead | x-ray diffraction | A, B | — | — |
| 4ZAE | Development of a novel class of potent and selective FIXa inhibitors | x-ray diffraction | A, B | — | — |
| 4ZAE | Development of a novel class of potent and selective fixa inhibitors | x-ray diffraction | A, B | — | — |
| 5EGM | Development of a novel tricyclic class of potent and selective FIXa inhibitors | x-ray diffraction | A, B | NA, 5NY | — |
| 5EGM | Development of a novel tricyclic class of potent and selective fixa inhibitors | x-ray diffraction | A, B | — | — |
| 5F84 | Crystal structure of Drosophila Poglut1 (Rumi) complexed with its glycoprotein product… | x-ray diffraction | B | BGC | 3 (best 0.79) |
| 5F84 | Crystal structure of drosophila POGLUT1 (rumi) complexed with its glycoprotein product… | x-ray diffraction | B | — | — |
| 5F85 | Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat)… | x-ray diffraction | B | — | — |
| 5F85 | Crystal structure of drosophila POGLUT1 (rumi) complexed with its substrate protein (EGF repeat)… | x-ray diffraction | B | — | — |
| 5F86 | Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) | x-ray diffraction | B | — | 2 (best 0.79) |
| 5F86 | Crystal structure of drosophila POGLUT1 (rumi) complexed with its substrate protein (EGF repeat) | x-ray diffraction | B | — | — |
33 records more on the page itself.
Ligands
- CA · Calcium ion · in 17 records
- NA · Sodium ion · in 11 records
- SO4 · Sulfate ion · in 4 records
- 0GJ · L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide · in 3 records
- BGC · beta-D-glucopyranose · in 3 records
- 6NH · 2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxamidine · in 2 records
- 7GQ · N-[(1S,4S,7R)-2-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl]-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide · in 2 records
- CL · Chloride ion · in 2 records
- PBZ · P-amino benzamidine · in 2 records
- UNL · Unknown ligand · in 2 records
- UQD · 3-chloro-4-{[5-hydroxy-6-(4-methylphenyl)pyrimidin-4-yl]amino}benzene-1-carboximidamide · in 2 records
- UQG · 4-{[5-hydroxy-6-(4-methylphenyl)pyrimidin-4-yl]amino}benzene-1-carboximidamide · in 2 records
- XYS · alpha-D-xylopyranose · in 2 records
- 0G6 · D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide · in 1 record
- 0QE · Chloromethane · in 1 record
- 5NY · 2-chloranyl-~{N}-[(7~{S})-2-methyl-7-phenyl-10-(1~{H}-1,2,3,4-tetrazol-5-yl)-8,9-dihydro-6~{H}-pyrido[1,2-a]indol-7-yl]-4-(1,2,4-triazol-4-yl)benzamide · in 1 record
- FUC · alpha-L-fucopyranose · in 1 record
Experiment against prediction
- 6X5P chain A against the predicted model P00740: TM-score 0.99, RMSD 0.77 Å
- 6X5P chain A against the predicted model P00740: TM-score 0.99, RMSD 0.77 Å
- 6X5L chain A against the predicted model P00740: TM-score 0.99, RMSD 0.79 Å
- 6X5L chain A against the predicted model P00740: TM-score 0.99, RMSD 0.79 Å
- 4Z0K chain A against the predicted model P00740: TM-score 0.99, RMSD 0.79 Å
- 4Z0K chain A against the predicted model P00740: TM-score 0.99, RMSD 0.79 Å
- 8OL9 chain H against the predicted model P00740: TM-score 0.98, RMSD 0.81 Å
- 1RFN chain A against the predicted model P00740: TM-score 0.98, RMSD 1.05 Å
- 1RFN chain A against the predicted model P00740: TM-score 0.98, RMSD 1.05 Å
- 6X5J chain A against the predicted model P00740: TM-score 0.98, RMSD 0.87 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.