UniProt P00375
P00375
P00375 (UniProt P00375): 12 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00375
- Experimental structures
- 12
- Predicted models
- 1
Structures
13 records of P00375 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U70 | Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and… | x-ray diffraction | A | — | — |
| 1U70 | Understanding the role of LEU22 variants in methotrexate resistance: comparison of wild-type and… | x-ray diffraction | A | — | — |
| 2FZJ | New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with… | x-ray diffraction | A | — | — |
| 2FZJ | New insights into DHFR interactions: analysis of pneumocystis carinii and mouse DHFR complexes with… | x-ray diffraction | A | — | — |
| 3D80 | Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a… | x-ray diffraction | A | — | — |
| 3D80 | Structural analysis of a holo enzyme complex of mouse dihydrofolate reductase with NADPH and a… | x-ray diffraction | A | — | — |
| 3D84 | Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a… | x-ray diffraction | X | — | — |
| 3D84 | Structural analysis of a holo enzyme complex of mouse dihydrofolate reductase with NADPH and a… | x-ray diffraction | X | — | — |
| 3K45 | Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as… | x-ray diffraction | A | — | — |
| 3K45 | Alternate binding modes observed for the E- and Z-isomers of 2,4- DIAMINOFURO[2,3D]PYRIMIDINES as… | x-ray diffraction | A | — | — |
| 3K47 | Alternate Binding Modes Observed for the E- and Z-Isomers of 2,4-Diaminofuro[2,3-d]pyrimidines as… | x-ray diffraction | A | — | — |
| 3K47 | Alternate binding modes observed for the E- and Z-isomers of 2,4- DIAMINOFURO[2,3-D]PYRIMIDINES as… | x-ray diffraction | A | — | — |
| P00375 | AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P00375) | predicted | A | — | — |
Experiment against prediction
- 3D84 chain X against the predicted model P00375: TM-score 0.97, RMSD 1.07 Å
- 3D84 chain X against the predicted model P00375: TM-score 0.97, RMSD 1.07 Å
- 2FZJ chain A against the predicted model P00375: TM-score 0.97, RMSD 1.04 Å
- 2FZJ chain A against the predicted model P00375: TM-score 0.97, RMSD 1.04 Å
- 3K47 chain A against the predicted model P00375: TM-score 0.97, RMSD 1.10 Å
- 3K47 chain A against the predicted model P00375: TM-score 0.97, RMSD 1.10 Å
- 3D80 chain A against the predicted model P00375: TM-score 0.97, RMSD 1.09 Å
- 3D80 chain A against the predicted model P00375: TM-score 0.97, RMSD 1.09 Å
- 3K45 chain A against the predicted model P00375: TM-score 0.97, RMSD 1.15 Å
- 3K45 chain A against the predicted model P00375: TM-score 0.97, RMSD 1.15 Å
Elsewhere
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