UniProt P00347
3-hydroxy-3-methylglutaryl-coenzyme A reductase (P00347)
3-hydroxy-3-methylglutaryl-coenzyme A reductase (UniProt P00347), EC 1.1.1.34: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 16 pockets. Binding sites, druggability and experiment against…
- UniProt
- P00347
- Protein
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- EC
- 1.1.1.34
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 16 · 3 records with a druggable one
Structures
5 records of P00347 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8DJK | HMGCR-UBIAD1 Complex State 2 | electron microscopy | A | Y01, AJP | 4 (best 0.72) |
| 8DJK | Hmgcr-UBIAD1 complex state 2 | electron microscopy | A | Y01, AJP | — |
| 8DJM | HMGCR-UBIAD1 Complex State 1 | electron microscopy | A | Y01, AJP | 4 (best 0.73) |
| 8DJM | Hmgcr-UBIAD1 complex state 1 | electron microscopy | A | Y01, AJP | — |
| P00347 | AlphaFold monomer V2.0 prediction for 3-hydroxy-3-methylglutaryl- coenzyme a reductase (P00347) | predicted | A | — | 8 (best 0.61) |
Ligands
Experiment against prediction
- 8DJM chain A against the predicted model P00347: TM-score 0.96, RMSD 1.21 Å
- 8DJM chain A against the predicted model P00347: TM-score 0.96, RMSD 1.21 Å
- 8DJK chain A against the predicted model P00347: TM-score 0.86, RMSD 2.37 Å
- 8DJK chain A against the predicted model P00347: TM-score 0.86, RMSD 2.37 Å
Elsewhere
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