UniProt P00336
L-lactate dehydrogenase B chain (P00336)
L-lactate dehydrogenase B chain (UniProt P00336), EC 1.1.1.27: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P00336
- Protein
- L-lactate dehydrogenase B chain
- EC
- 1.1.1.27
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 1 record with a druggable one
Structures
7 records of P00336 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LDH | Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7… | x-ray diffraction | A, B | LNC | — |
| 5LDH | Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7… | x-ray diffraction | A, B | ACE, LNC | — |
| 5YTA | Pig Heart Lactate Dehydrogenase in complex with NADH and Oxamate | x-ray diffraction | A, B | NAD, OXM | — |
| 5YTA | Pig heart lactate dehydrogenase in complex with NADH and oxamate | x-ray diffraction | A, B | NAD, OXM | — |
| 6CEP | Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate | x-ray diffraction | A, B, C, D | NAD, OXM | 17 (best 0.87) |
| 6CEP | Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate | x-ray diffraction | A, B, C, D | NAD, OXM | — |
| P00336 | AlphaFold monomer V2.0 prediction for L-lactate dehydrogenase B chain (P00336) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6CEP chain B against the predicted model P00336: TM-score 0.99, RMSD 0.72 Å
- 6CEP chain B against the predicted model P00336: TM-score 0.99, RMSD 0.72 Å
- 6CEP chain D against the predicted model P00336: TM-score 0.99, RMSD 0.73 Å
- 6CEP chain D against the predicted model P00336: TM-score 0.99, RMSD 0.73 Å
- 5YTA chain A against the predicted model P00336: TM-score 0.98, RMSD 1.39 Å
- 5YTA chain A against the predicted model P00336: TM-score 0.98, RMSD 1.39 Å
- 6CEP chain A against the predicted model P00336: TM-score 0.98, RMSD 1.38 Å
- 6CEP chain A against the predicted model P00336: TM-score 0.98, RMSD 1.38 Å
- 6CEP chain C against the predicted model P00336: TM-score 0.98, RMSD 1.40 Å
- 5LDH chain A against the predicted model P00336: TM-score 0.91, RMSD 2.46 Å
Elsewhere
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