UniProt O96028
Histone-lysine N-methyltransferase NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (UniProt O96028), EC 2.1.1.357, 2.1.1.43: 17 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 74 pockets. Binding sites, druggability and experiment against…
- UniProt
- O96028
- Protein
- Histone-lysine N-methyltransferase NSD2
- EC
- 2.1.1.357, 2.1.1.43
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 74 · 7 records with a druggable one
Structures
18 records of O96028 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LSU | Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives | x-ray diffraction | A, B | ZN, SAM | 8 (best 0.68) |
| 5LSU | Structure of the epigenetic oncogene mmset and inhibition by N-alkyl sinefungin derivatives | x-ray diffraction | A, B | ZN | — |
| 5VC8 | Crystal structure of the WHSC1 PWWP1 domain | x-ray diffraction | A, B | UNX | 1 (best 0.78) |
| 5VC8 | Crystal structure of the WHSC1 PWWP1 domain | x-ray diffraction | A, B | UNX | — |
| 6UE6 | PWWP1 domain of NSD2 in complex with MR837 | x-ray diffraction | A, B, C, D, E, F, G, H | Q5D, UNX | 20 (best 0.67) |
| 6UE6 | PWWP1 domain of NSD2 in complex with MR837 | x-ray diffraction | A, B, C, D, E, F, G, H | Q5D, UNX | — |
| 6XCG | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934 | x-ray diffraction | A, B, C | V01, UNX | — |
| 7CRO | NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP | electron microscopy | I | ZN | — |
| 7CRO | NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp ncp | electron microscopy | I | ZN | — |
| 7E8D | NSD2 E1099K mutant bound to nucleosome | electron microscopy | K | ZN | — |
| 7LMT | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866A | x-ray diffraction | A, B, C, D, E, F, G, H | Y6V, UNX | — |
| 7MDN | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a | x-ray diffraction | A, B, C, D, E, F, G, H | Y6V, UNX | 20 (best 0.74) |
| 7MDN | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866A | — | — | — | |
| 7VLN | NSD2-PWWP1 domain bound with an imidazol-5-yl benzonitrile compound | x-ray diffraction | A, B, C | 7QC | — |
| 9EXW | Crystal structure of the PWWP1 domain of NSD2 bound by compound 17. | x-ray diffraction | A, B | A1H7X | 5 (best 0.68) |
| 9EXY | Crystal structure of the PWWP1 domain of NSD2 bound by compound 34. | x-ray diffraction | A, B | A1H7Z | 4 (best 0.39) |
| 9GBF | X-RAY structure of PHDvC5HCH tandem domain of NSD2 | x-ray diffraction | A, B | ZN, NA | 2 (best 0.59) |
| O96028 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase NSD2 (O96028) | predicted | A | — | 14 (best 0.74) |
Ligands
- UNX · Unknown atom or ion · in 7 records
- ZN · Zinc ion · in 6 records
- Q5D · 4-cyano-N-cyclopropyl-N-[(thiophen-2-yl) methyl]benzamide · in 2 records
- Y6V · ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide · in 2 records
- 7QC · 4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile · in 1 record
- A1H7X · 7-[3-methyl-5-[2-methyl-5-[(pyridin-3-ylamino)methyl]phenyl]imidazol-4-yl]-4~{H}-1,4-benzoxazin-3-one · in 1 record
- A1H7Z · 7-[5-methyl-3-[2-methyl-5-(piperidin-1-ylmethyl)phenyl]-1,2-oxazol-4-yl]-4~{H}-1,4-benzoxazin-3-one · in 1 record
- NA · Sodium ion · in 1 record
- SAM · S-adenosylmethionine · in 1 record
- V01 · N-cyclopropyl-3-oxo-N-({4-[(pyrimidin-4-yl) carbamoyl]phenyl}methyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carboxamide · in 1 record
Experiment against prediction
- 6UE6 chain F against the predicted model O96028: TM-score 0.97, RMSD 0.73 Å
- 6UE6 chain F against the predicted model O96028: TM-score 0.97, RMSD 0.73 Å
- 7LMT chain F against the predicted model O96028: TM-score 0.97, RMSD 0.83 Å
- 7MDN chain F against the predicted model O96028: TM-score 0.97, RMSD 0.83 Å
- 9EXW chain B against the predicted model O96028: TM-score 0.97, RMSD 0.82 Å
- 6UE6 chain C against the predicted model O96028: TM-score 0.97, RMSD 0.79 Å
- 6UE6 chain C against the predicted model O96028: TM-score 0.97, RMSD 0.79 Å
- 7LMT chain C against the predicted model O96028: TM-score 0.96, RMSD 0.85 Å
- 7MDN chain C against the predicted model O96028: TM-score 0.96, RMSD 0.85 Å
- 7E8D chain K against the predicted model O96028: TM-score 0.96, RMSD 1.25 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.