UniProt O96017
O96017
O96017 (UniProt O96017): 70 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O96017
- Experimental structures
- 70
- Predicted models
- 1
Structures
71 records of O96017 in the MolNFT archive: 70 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GXC | FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide | x-ray diffraction | A, D, G, J | — | — |
| 1GXC | Fha domain from human CHK2 kinase in complex with a synthetic phosphopeptide | x-ray diffraction | A, D, G, J | — | — |
| 2CN5 | Crystal structure of human Chk2 in complex with ADP | x-ray diffraction | A | — | — |
| 2CN5 | Crystal structure of human CHK2 in complex with ADP | x-ray diffraction | A | — | — |
| 2CN8 | Crystal structure of human Chk2 in complex with debromohymenialdisine | x-ray diffraction | A | — | — |
| 2CN8 | Crystal structure of human CHK2 in complex with debromohymenialdisine | x-ray diffraction | A | — | — |
| 2W0J | Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor | x-ray diffraction | A | — | — |
| 2W0J | Crystal structure of CHK2 in complex with nsc 109555, a specific inhibitor | x-ray diffraction | A | — | — |
| 2W7X | Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2… | x-ray diffraction | A | — | — |
| 2W7X | Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel CHK2… | x-ray diffraction | A | — | — |
| 2WTC | Crystal structure of CHK2 in complex with an inhibitor | x-ray diffraction | A | — | — |
| 2WTC | Crystal structure of CHK2 in complex with an inhibitor | x-ray diffraction | A | — | — |
| 2WTD | Crystal structure of Chk2 in complex with an inhibitor | x-ray diffraction | A | — | — |
| 2WTD | Crystal structure of CHK2 in complex with an inhibitor | x-ray diffraction | A | — | — |
| 2XBJ | Crystal Structure of Chk2 in complex with an inhibitor | x-ray diffraction | A | — | — |
| 2XBJ | Crystal structure of CHK2 in complex with an inhibitor | x-ray diffraction | A | — | — |
| 2XM8 | Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2 | x-ray diffraction | A | — | — |
| 2XM8 | Co-crystal structure of a small molecule inhibitor bound to the kinase domain of CHK2 | x-ray diffraction | A | — | — |
| 2XM9 | Structure of a small molecule inhibitor with the kinase domain of Chk2 | x-ray diffraction | A | — | — |
| 2XM9 | Structure of a small molecule inhibitor with the kinase domain of CHK2 | x-ray diffraction | A | — | — |
| 2YCF | Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531 | x-ray diffraction | A | — | — |
| 2YCF | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1531 | x-ray diffraction | A | — | — |
| 2YCQ | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115 | x-ray diffraction | A | — | — |
| 2YCQ | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115 | x-ray diffraction | A | — | — |
| 2YCR | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976 | x-ray diffraction | A | — | — |
| 2YCR | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976 | x-ray diffraction | A | — | — |
| 2YCS | Crystal structure of checkpoint kinase 2 in complex with PV788 | x-ray diffraction | A | — | — |
| 2YCS | Crystal structure of checkpoint kinase 2 in complex with PV788 | x-ray diffraction | A | — | — |
| 2YIQ | Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322 | x-ray diffraction | A | — | — |
| 2YIQ | Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322 | x-ray diffraction | A | — | — |
| 2YIR | Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352 | x-ray diffraction | A | — | — |
| 2YIR | Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352 | x-ray diffraction | A | — | — |
| 2YIT | Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor | x-ray diffraction | A | — | — |
| 2YIT | Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor | x-ray diffraction | A | — | — |
| 3I6U | Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase | x-ray diffraction | A, B | — | — |
| 3I6U | Structure and activation mechanism of the CHK2 DNA-damage checkpoint kinase | x-ray diffraction | A, B | — | — |
| 3I6W | Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3I6W | Structure and activation mechanism of the CHK2 DNA-damage checkpoint kinase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3VA4 | Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide | x-ray diffraction | C | — | — |
| 3VA4 | Crystal structure of the mammalian MDC1 fha domain complexed with CHK2 PTHR68 peptide | x-ray diffraction | C | — | — |
| 4A9R | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9R | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9S | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9S | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9T | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9T | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9U | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4A9U | Crystal structure of human CHK2 in complex with benzimidazole carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4BDA | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDA | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDB | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDB | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDC | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDC | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDD | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDD | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDE | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDE | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDF | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
| 4BDF | Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) | x-ray diffraction | A | — | — |
11 records more on the page itself.
Experiment against prediction
- 1GXC chain D against the predicted model O96017: TM-score 0.98, RMSD 0.69 Å
- 1GXC chain D against the predicted model O96017: TM-score 0.98, RMSD 0.69 Å
- 1GXC chain J against the predicted model O96017: TM-score 0.97, RMSD 0.86 Å
- 1GXC chain J against the predicted model O96017: TM-score 0.97, RMSD 0.86 Å
- 1GXC chain G against the predicted model O96017: TM-score 0.97, RMSD 0.80 Å
- 1GXC chain G against the predicted model O96017: TM-score 0.97, RMSD 0.80 Å
- 1GXC chain A against the predicted model O96017: TM-score 0.97, RMSD 0.91 Å
- 1GXC chain A against the predicted model O96017: TM-score 0.97, RMSD 0.91 Å
- 2XM8 chain A against the predicted model O96017: TM-score 0.88, RMSD 1.84 Å
- 2XM8 chain A against the predicted model O96017: TM-score 0.88, RMSD 1.84 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.