UniProt O95747
Serine/threonine-protein kinase OSR1 (O95747)
Serine/threonine-protein kinase OSR1 (UniProt O95747), EC 2.7.11.1: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O95747
- Protein
- Serine/threonine-protein kinase OSR1
- EC
- 2.7.11.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 12 · 1 record with a druggable one
Structures
9 records of O95747 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V3S | Structural insights into the recognition of substrates and activators by the OSR1 kinase | x-ray diffraction | A, B | — | — |
| 2V3S | Structural insights into the recognition of substrates and activators by the OSR1 kinase | x-ray diffraction | A, B | — | — |
| 2VWI | Structure of the OSR1 kinase, a hypertension drug target | x-ray diffraction | A, B, C, D | — | — |
| 2VWI | Structure of the OSR1 kinase, a hypertension drug target | x-ray diffraction | A, B, C, D | — | — |
| 3DAK | Crystal Structure of Domain-Swapped OSR1 kinase domain | x-ray diffraction | A, B, C, D | — | — |
| 3DAK | Crystal structure of domain-swapped OSR1 kinase domain | x-ray diffraction | A, B, C, D | — | — |
| 7OKW | 1.62A X-ray crystal structure of the conserved C-terminal (CCT) of human OSR1 | x-ray diffraction | A, B | CA, MG, NA | 5 (best 0.49) |
| 7OKW | 1.62A X-ray crystal structure of the conserved C-terminal (cct) of human OSR1 | x-ray diffraction | A, B | CA, NA, MG | — |
| O95747 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase OSR1 (O95747) | predicted | A | — | 7 (best 0.68) |
Ligands
Experiment against prediction
- 2V3S chain A against the predicted model O95747: TM-score 0.95, RMSD 0.90 Å
- 2V3S chain A against the predicted model O95747: TM-score 0.95, RMSD 0.90 Å
- 7OKW chain B against the predicted model O95747: TM-score 0.95, RMSD 0.92 Å
- 3DAK chain B against the predicted model O95747: TM-score 0.94, RMSD 1.10 Å
- 3DAK chain B against the predicted model O95747: TM-score 0.94, RMSD 1.10 Å
- 7OKW chain A against the predicted model O95747: TM-score 0.94, RMSD 1.00 Å
- 7OKW chain A against the predicted model O95747: TM-score 0.94, RMSD 1.00 Å
- 2VWI chain B against the predicted model O95747: TM-score 0.94, RMSD 1.39 Å
- 2VWI chain B against the predicted model O95747: TM-score 0.94, RMSD 1.39 Å
- 3DAK chain A against the predicted model O95747: TM-score 0.94, RMSD 1.14 Å
Elsewhere
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