UniProt O95696
Bromodomain-containing protein 1 (O95696)
Bromodomain-containing protein 1 (UniProt O95696): 452 experimental structures and 1 predicted model on GenesisL1, 40 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95696
- Protein
- Bromodomain-containing protein 1
- Experimental structures
- 452
- Predicted models
- 1
- Ligands
- 40
- Pockets
- 36 · 4 records with a druggable one
Structures
453 records of O95696 in the MolNFT archive: 452 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KU3 | Solution structure of BRD1 PHD1 finger | solution nmr | A | — | — |
| 2KU3 | Solution structure of BRD1 PHD1 finger | solution nmr | A | — | — |
| 2L43 | Structural basis for histone code recognition by BRPF2-PHD1 finger | solution nmr | A | — | — |
| 2L43 | Structural basis for histone code recognition by BRPF2-PHD1 finger | solution nmr | A | — | — |
| 2LQ6 | Solution structure of BRD1 PHD2 finger | solution nmr | A | — | — |
| 2LQ6 | Solution structure of BRD1 PHD2 finger | solution nmr | A | — | — |
| 3LYI | PWWP Domain of Human Bromodomain-Containing Protein 1 | x-ray diffraction | A, B | — | — |
| 3LYI | Pwwp domain of human bromodomain-containing protein 1 | x-ray diffraction | A, B | — | — |
| 3RCW | Crystal Structure of the bromodomain of human BRD1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3RCW | Crystal structure of the bromodomain of human BRD1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4Z02 | Crystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acid | x-ray diffraction | A, B | — | — |
| 4Z02 | Crystal structure of BRD1 in complex with isoquinoline-3-carboxylic acid | x-ray diffraction | A, B | — | — |
| 5AME | Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D… | x-ray diffraction | A, B | — | — |
| 5AME | Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D… | x-ray diffraction | A, B | — | — |
| 5AMF | Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D… | x-ray diffraction | A, B | — | — |
| 5AMF | Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D… | x-ray diffraction | A, B | — | — |
| 5FG6 | Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with of-1 chemical probe | x-ray diffraction | A | — | — |
| 5N49 | BRPF2 in complex with Compound 7 | x-ray diffraction | A, B | 8LW | 3 (best 0.56) |
| 5N49 | BRPF2 in complex with compound 7 | x-ray diffraction | A, B | 8LW | — |
| 5PNX | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10128A | x-ray diffraction | A, B | M3I, NA | — |
| 5PNY | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10174a | x-ray diffraction | A, B | NA, 8S1 | 4 (best 0.49) |
| 5PNY | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10174A | x-ray diffraction | A, B | NA, 8S1 | — |
| 5PNZ | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10162A | x-ray diffraction | A, B | NA, 8S4 | — |
| 5PO0 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10146A | x-ray diffraction | A, B | NA, 8S7 | — |
| 5PO1 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10152A | x-ray diffraction | A, B | NA, 8SA | — |
| 5PO2 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10132A | x-ray diffraction | A, B | 8SD, NA | — |
| 5PO3 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10164A | x-ray diffraction | A, B | NA, 8SG | — |
| 5PO4 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10170A | x-ray diffraction | A, B | NA, 8SJ | — |
| 5PO5 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10192A | x-ray diffraction | A, B | NA, 8SM | — |
| 5PO6 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10157A | x-ray diffraction | A, B | 8SS, NA | — |
| 5PO7 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11083A | x-ray diffraction | A, B | 8SV, NA | — |
| 5PO8 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N07808B | x-ray diffraction | A, B | 8SY, NA | — |
| 5PO9 | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N07950B | x-ray diffraction | A, B | 8T7, NA | — |
| 5POA | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10186A | x-ray diffraction | A, B | NA, 8TA | — |
| 5POB | Pandda analysis group deposition -- crystal structure of BRD1 in complex with E13683B | x-ray diffraction | A, B | 8TD, NA | — |
| 5POC | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11081A | x-ray diffraction | A, B | 8TG, NA | — |
| 5POD | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N07807B | x-ray diffraction | A, B | 8T1, NA | — |
| 5POE | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10188A and N07807B | x-ray diffraction | A, B | 8T1, NA, 8T4 | — |
| 5POF | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10941A | x-ray diffraction | A, B | NA, 8RV | — |
| 5POG | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11063A | x-ray diffraction | A, B | 8TJ, NA | — |
| 5POH | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11029A | x-ray diffraction | A, B | 8TP, NA | — |
| 5POI | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11016A | x-ray diffraction | A, B | 8RY, NA | — |
| 5POJ | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10941A | x-ray diffraction | A, B | 8RV, NA | — |
| 5POK | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10908A | x-ray diffraction | A, B | 8RS, NA | — |
| 5POL | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10971a | x-ray diffraction | A, B | 8RP, NA | 3 (best 0.55) |
| 5POL | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10971A | x-ray diffraction | A, B | 8RP, NA | — |
| 5POM | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10958A | x-ray diffraction | A, B | NA, 8RM | — |
| 5PON | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10980A | x-ray diffraction | A, B | 8RA, NA | — |
| 5POO | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10966A | x-ray diffraction | A, B | NA, 8TS | — |
| 5POP | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10987A | x-ray diffraction | A, B | 8TV, NA | — |
| 5POQ | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10974A | x-ray diffraction | A, B | 8TY, NA | — |
| 5POR | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10982A | x-ray diffraction | A, B | PW3, NA | — |
| 5POS | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10919A | x-ray diffraction | A, B | 8U1, NA | — |
| 5POT | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10931A | x-ray diffraction | A, B | 8U4, NA | — |
| 5POU | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10954a | x-ray diffraction | A, B | NA, 8U7 | 4 (best 0.49) |
| 5POU | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10954A | x-ray diffraction | A, B | NA, 8U7 | — |
| 5POV | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11063A | x-ray diffraction | A, B | 8TJ, NA | — |
| 5POW | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N10894B | x-ray diffraction | A, B | 8UA, NA | — |
| 5POX | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N11075a | x-ray diffraction | A, B | 8UG, NA | 4 (best 0.48) |
| 5POX | Pandda analysis group deposition -- crystal structure of BRD1 in complex with N11075A | x-ray diffraction | A, B | 8UG, NA | — |
393 records more on the page itself.
Ligands
- NA · Sodium ion · in 305 records
- 8LW · 2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl) benzo[de]isoquinoline-1,3-dione · in 2 records
- 8RP · 1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one · in 2 records
- 8RV · N-(1-benzylpiperidin-4-yl)acetamide · in 2 records
- 8S1 · 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile · in 2 records
- 8T1 · 6-amino-1-methylquinolin-2(1H)-one · in 2 records
- 8TJ · N-methylthieno[2,3-b]pyridine-2-carboxamide · in 2 records
- 8TP · N-[2-(phenylamino)ethyl]acetamide · in 2 records
- 8U7 · N-(1-benzylpiperidin-4-yl)-N'-methylurea · in 2 records
- 8UG · ethyl (5S)-4,5,6,7-tetrahydro-2H-indazole-5-carboxylate · in 2 records
- O4B · 1,4,7,10,13,16-hexaoxacyclooctadecane · in 2 records
- 8RA · 1-[4-(pyridin-2-yl)piperazin-1-yl]ethan-1-one · in 1 record
- 8RM · N-methylquinoline-3-carboxamide · in 1 record
- 8RS · 1-(4-phenylpiperazin-1-yl)ethan-1-one · in 1 record
- 8RY · N-methylpyrimidine-2-carboxamide · in 1 record
- 8S4 · 1-[(4-methoxyphenyl)methyl]-1H-tetrazole · in 1 record
- 8S7 · N-(3-methyl-1,2-oxazol-5-yl)cyclopropanecarboxamide · in 1 record
- 8SA · 5-methyl-N-[(thiophen-2-yl)methyl]-1,2-oxazol-3-amine · in 1 record
- 8SD · 5-hydroxy-1,3-dihydro-2H-indol-2-one · in 1 record
- 8SG · N-(3-methyl-1,2-oxazol-5-yl)furan-2-carboxamide · in 1 record
- 8SJ · (4-nitrophenyl)methyl carbamimidothioate · in 1 record
- 8SM · 2-[1-methyl-3-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl]pyridine · in 1 record
- 8SS · 4-(4-bromophenyl)-1H-pyrazol-3-amine · in 1 record
- 8SV · 1,3-dimethyl-5-(methylamino)-6-nitro-1,3-dihydro-2H-benzimidazol-2-one · in 1 record
- 8SY · 6-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one · in 1 record
- 8T4 · 1-methyl-4-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole · in 1 record
- 8T7 · 1-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine · in 1 record
- 8TA · 2-[5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl]pyridine · in 1 record
- 8TD · 5-amino-1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-one · in 1 record
- 8TG · 7-bromo-1-methyl-6-nitroquinolin-2(1H)-one · in 1 record
Experiment against prediction
- 3RCW chain G against the predicted model O95696: TM-score 0.98, RMSD 0.53 Å
- 3RCW chain G against the predicted model O95696: TM-score 0.98, RMSD 0.53 Å
- 3RCW chain H against the predicted model O95696: TM-score 0.98, RMSD 0.55 Å
- 3RCW chain H against the predicted model O95696: TM-score 0.98, RMSD 0.55 Å
- 3LYI chain B against the predicted model O95696: TM-score 0.98, RMSD 0.54 Å
- 3LYI chain B against the predicted model O95696: TM-score 0.98, RMSD 0.54 Å
- 3RCW chain D against the predicted model O95696: TM-score 0.98, RMSD 0.77 Å
- 3RCW chain D against the predicted model O95696: TM-score 0.98, RMSD 0.77 Å
- 3RCW chain C against the predicted model O95696: TM-score 0.98, RMSD 0.61 Å
- 3RCW chain C against the predicted model O95696: TM-score 0.98, RMSD 0.61 Å
Elsewhere
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