UniProt O95619
YEATS domain-containing protein 4 (O95619)
YEATS domain-containing protein 4 (UniProt O95619): 15 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95619
- Protein
- YEATS domain-containing protein 4
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 15 · 4 records with a druggable one
Structures
16 records of O95619 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5R68 | Xchem group deposition -- crystal structure of human YEATS4 in complex with FM000199E | x-ray diffraction | B, A | RYD | — |
| 5R69 | XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e | x-ray diffraction | B, A | ZHA | 1 (best 0.62) |
| 5R69 | Xchem group deposition -- crystal structure of human YEATS4 in complex with XS038644E | x-ray diffraction | B, A | ZHA | — |
| 5VNA | Crystal structure of human yeats domain | x-ray diffraction | A, B, C, D | SO4 | — |
| 5VNB | YEATS in complex with histone H3 | x-ray diffraction | A, B, C, D | SO4 | — |
| 5VNB | Yeats in complex with histone H3 | x-ray diffraction | A, B, C, D | SO4 | — |
| 5XTZ | Crystal structure of GAS41 yeats bound to H3K27AC peptide | x-ray diffraction | A, B, C, D | — | — |
| 5Y8V | Crystal structure of GAS41 | x-ray diffraction | B, A, C, D | MG | — |
| 7EIF | Crystal structure of GAS41 YEATS domain | x-ray diffraction | A | — | — |
| 7EIF | Crystal structure of GAS41 yeats domain | x-ray diffraction | A | — | — |
| 7JFY | GAS41 yeats domain in complex with 5 | x-ray diffraction | B, A, C, D | V91 | — |
| 8DKB | Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b | x-ray diffraction | A, B, C, D, E, F, G, H | SJI | 7 (best 0.70) |
| 8I60 | Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr | x-ray diffraction | C, D | SO4 | 2 (best 0.64) |
| 8IIY | Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K14ac peptide | x-ray diffraction | A | GLC | 3 (best 0.71) |
| 8X15 | Structure of nucleosome-bound SRCAP-C in the apo state | electron microscopy | W | — | — |
| O95619 | AlphaFold monomer V2.0 prediction for yeats domain-containing protein 4 (O95619) | predicted | A | — | 2 (best 0.35) |
Ligands
- SO4 · Sulfate ion · in 4 records
- ZHA · ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide · in 2 records
- GLC · alpha-D-glucopyranose · in 1 record
- MG · Magnesium ion · in 1 record
- RYD · (1-methylbenzotriazol-5-yl)methanol · in 1 record
- SJI · N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide · in 1 record
- V91 · N-(5-{3-[(2S)-1,3-thiazolidin-2-yl]azetidine-1-carbonyl}thiophen-2-yl)-L-prolinamide · in 1 record
Experiment against prediction
- 5XTZ chain B against the predicted model O95619: TM-score 0.99, RMSD 0.52 Å
- 5Y8V chain D against the predicted model O95619: TM-score 0.98, RMSD 0.60 Å
- 5R68 chain A against the predicted model O95619: TM-score 0.98, RMSD 0.68 Å
- 7EIF chain A against the predicted model O95619: TM-score 0.98, RMSD 0.80 Å
- 7EIF chain A against the predicted model O95619: TM-score 0.98, RMSD 0.80 Å
- 8DKB chain B against the predicted model O95619: TM-score 0.98, RMSD 0.68 Å
- 5Y8V chain B against the predicted model O95619: TM-score 0.98, RMSD 0.70 Å
- 8DKB chain F against the predicted model O95619: TM-score 0.97, RMSD 0.69 Å
- 5XTZ chain A against the predicted model O95619: TM-score 0.97, RMSD 0.73 Å
- 8DKB chain G against the predicted model O95619: TM-score 0.97, RMSD 0.70 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.