UniProt O95402
Mediator of RNA polymerase II transcription subunit 26 (O95402)
Mediator of RNA polymerase II transcription subunit 26 (UniProt O95402): 10 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95402
- Protein
- Mediator of RNA polymerase II transcription subunit 26
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
11 records of O95402 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ODD | Human MED26 N-terminal domain (1-92) | solution nmr | A | — | 1 (best 0.59) |
| 5ODD | Human MED26 N-terminal domain (1-92) | solution nmr | A | — | — |
| 6ZV3 | TFIIS N-terminal domain (TND) from human MED26 | solution nmr | A | — | 1 (best 0.29) |
| 6ZV3 | Tfiis N-terminal domain (tnd) from human MED26 | solution nmr | A | — | — |
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | Z | — | 1 (best 0.74) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | Z | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | z | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | z | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | Z | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | z | — | — |
| O95402 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 26… | predicted | A | — | — |
Experiment against prediction
- 6ZV3 chain A against the predicted model O95402: TM-score 0.90, RMSD 1.35 Å
- 6ZV3 chain A against the predicted model O95402: TM-score 0.90, RMSD 1.35 Å
- 5ODD chain A against the predicted model O95402: TM-score 0.69, RMSD 2.84 Å
- 5ODD chain A against the predicted model O95402: TM-score 0.69, RMSD 2.84 Å
- 7ENC chain z against the predicted model O95402: TM-score 0.69, RMSD 2.20 Å
- 7ENA chain z against the predicted model O95402: TM-score 0.68, RMSD 2.23 Å
- 8GXQ chain z against the predicted model O95402: TM-score 0.68, RMSD 2.26 Å
- 7EMF chain Z against the predicted model O95402: TM-score 0.68, RMSD 2.41 Å
- 7EMF chain Z against the predicted model O95402: TM-score 0.68, RMSD 2.41 Å
- 7ENJ chain Z against the predicted model O95402: TM-score 0.68, RMSD 2.41 Å
Elsewhere
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