UniProt O95390
Growth/differentiation factor 11 (O95390)
Growth/differentiation factor 11 (UniProt O95390): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95390
- Protein
- Growth/differentiation factor 11
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 21 · 4 records with a druggable one
Structures
11 records of O95390 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5E4G | Crystal structure of human growth differentiation factor 11 (GDF-11) | x-ray diffraction | A | — | — |
| 5E4G | Crystal structure of human growth differentiation factor 11 (gdf-11) | x-ray diffraction | A | — | — |
| 5JHW | Crystal Structure of the GDF11:Follistatin 288 complex | x-ray diffraction | A, B | PO4 | 13 (best 0.71) |
| 5JHW | Crystal structure of the GDF11:FOLLISTATIN 288 complex | x-ray diffraction | A, B | — | — |
| 5UHM | Apo-Structure of Mature Growth Differentiation Factor 11 | x-ray diffraction | A, B | — | 1 (best 0.69) |
| 5UHM | Apo-structure of mature growth differentiation factor 11 | x-ray diffraction | A, B | — | — |
| 6MAC | Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD | x-ray diffraction | A | — | 4 (best 0.60) |
| 6MAC | Ternary structure of GDF11 bound to actriib-ecd and ALK5-ecd | x-ray diffraction | A | — | — |
| 7MRZ | Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment | x-ray diffraction | A | — | 3 (best 0.55) |
| 7MRZ | Structure of GDF11 bound to fused actriib-ecd and ALK4-ecd with anti- actriib Fab fragment | x-ray diffraction | A | — | — |
| O95390 | AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 11 (O95390) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 5UHM chain A against the predicted model O95390: TM-score 0.89, RMSD 1.48 Å
- 5UHM chain A against the predicted model O95390: TM-score 0.89, RMSD 1.48 Å
- 5UHM chain B against the predicted model O95390: TM-score 0.87, RMSD 1.55 Å
- 5UHM chain B against the predicted model O95390: TM-score 0.87, RMSD 1.55 Å
- 5E4G chain A against the predicted model O95390: TM-score 0.79, RMSD 1.37 Å
- 5E4G chain A against the predicted model O95390: TM-score 0.79, RMSD 1.37 Å
- 5JHW chain A against the predicted model O95390: TM-score 0.78, RMSD 1.31 Å
- 5JHW chain A against the predicted model O95390: TM-score 0.78, RMSD 1.31 Å
- 7MRZ chain A against the predicted model O95390: TM-score 0.77, RMSD 2.16 Å
- 7MRZ chain A against the predicted model O95390: TM-score 0.77, RMSD 2.16 Å
Elsewhere
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