UniProt O88602
Voltage-dependent calcium channel gamma-2 subunit (O88602)
Voltage-dependent calcium channel gamma-2 subunit (UniProt O88602): 25 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 195 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O88602
- Protein
- Voltage-dependent calcium channel gamma-2 subunit
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 195 · 19 records with a druggable one
Structures
26 records of O88602 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JXT | Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based… | x-ray diffraction | C, D | — | — |
| 3JXT | Crystal structure of the third PDZ domain of sap-102 in complex with a fluorogenic peptide-based… | x-ray diffraction | C, D | — | — |
| 5KBS | Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution | electron microscopy | A, B, C, D | ZK1, NAG | 20 (best 0.84) |
| 5KBS | Cryo-EM structure of GLUA2-0XSTZ at 8.7 ångström resolution | electron microscopy | A, B, C, D | ZK1, NAG | — |
| 5KBT | Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution | electron microscopy | A, B, C, D | ZK1, NAG | 20 (best 0.84) |
| 5KBT | Cryo-EM structure of GLUA2-1XSTZ complex at 6.4 ångström resolution | electron microscopy | A, B, C, D | ZK1, NAG | — |
| 5KBU | Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution | electron microscopy | A, B, C, D | ZK1, NAG | 20 (best 0.84) |
| 5KBU | Cryo-EM structure of GLUA2-2XSTZ complex at 7.8 ångström resolution | electron microscopy | A, B, C, D | ZK1, NAG | — |
| 5WEO | Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin | electron microscopy | A, B, C, D | GLU, CYZ | 20 (best 0.87) |
| 5WEO | Activated GLUA2 complex bound to glutamate, cyclothiazide, and stz in digitonin | electron microscopy | A, B, C, D | CYZ | — |
| 8FP4 | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM… | electron microscopy | E, G, F, H | CL | 9 (best 0.66) |
| 8FP9 | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM… | electron microscopy | E, G, F, H | CL | 10 (best 0.63) |
| 8FPG | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM… | electron microscopy | H, F, E, G | CL | 8 (best 0.63) |
| 8FPS | GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2… | electron microscopy | E, G, F, H | CL | 10 (best 0.64) |
| 8FQ1 | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM… | electron microscopy | E, G, F, H | — | 8 (best 0.71) |
| 8FQ5 | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM… | electron microscopy | E, G, F, H | CL | 8 (best 0.69) |
| 8FQB | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM… | electron microscopy | E, G, F, H | CL | 9 (best 0.68) |
| 8FQF | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM… | electron microscopy | E, G, F, H | CL | 11 (best 0.67) |
| 9B5Z | GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 6 (best 0.75) |
| 9B60 | GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 8 (best 0.58) |
| 9B61 | GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 4 (best 0.67) |
| 9B63 | GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 7 (best 0.62) |
| 9B64 | GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 6 (best 0.66) |
| 9B67 | GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 5 (best 0.72) |
| 9B6A | GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 | electron microscopy | H, F, E, G | — | 6 (best 0.70) |
| O88602 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-2 subunit (O88602) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8FP9 chain E against the predicted model O88602: TM-score 0.97, RMSD 0.99 Å
- 8FQB chain E against the predicted model O88602: TM-score 0.97, RMSD 1.00 Å
- 8FP9 chain G against the predicted model O88602: TM-score 0.97, RMSD 1.01 Å
- 8FQB chain G against the predicted model O88602: TM-score 0.97, RMSD 1.00 Å
- 9B61 chain F against the predicted model O88602: TM-score 0.97, RMSD 1.04 Å
- 9B6A chain H against the predicted model O88602: TM-score 0.97, RMSD 1.04 Å
- 9B61 chain H against the predicted model O88602: TM-score 0.97, RMSD 1.05 Å
- 8FPS chain E against the predicted model O88602: TM-score 0.97, RMSD 1.02 Å
- 8FPS chain G against the predicted model O88602: TM-score 0.97, RMSD 1.02 Å
- 9B64 chain H against the predicted model O88602: TM-score 0.97, RMSD 1.06 Å
Elsewhere
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