UniProt O80992
Abscisic acid receptor PYL2 (O80992)
Abscisic acid receptor PYL2 (UniProt O80992): 54 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O80992
- Protein
- Abscisic acid receptor PYL2
- Experimental structures
- 54
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 19 · 7 records with a druggable one
Structures
55 records of O80992 in the MolNFT archive: 54 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3KAZ | Crystal structure of abscisic acid receptor PYL2 | x-ray diffraction | A, B, C | — | — |
| 3KAZ | Crystal structure of abscisic acid receptor PYL2 | x-ray diffraction | A, B, C | — | — |
| 3KB0 | Crystal structure of abscisic acid-bound PYL2 | x-ray diffraction | A | — | — |
| 3KB0 | Crystal structure of abscisic acid-bound PYL2 | x-ray diffraction | A | — | — |
| 3KB3 | Crystal structure of abscisic acid-bound PYL2 in complex with HAB1 | x-ray diffraction | A | — | — |
| 3KB3 | Crystal structure of abscisic acid-bound PYL2 in complex with HAB1 | x-ray diffraction | A | — | — |
| 3KDH | Structure of ligand-free PYL2 | x-ray diffraction | A, B, C | — | — |
| 3KDH | Structure of ligand-free PYL2 | x-ray diffraction | A, B, C | — | — |
| 3KDI | Structure of (+)-ABA bound PYL2 | x-ray diffraction | A | — | — |
| 3KDI | Structure of (+)-aba bound PYL2 | x-ray diffraction | A | — | — |
| 3KL1 | Crystal structure of abscisic acid receptor PYL2 at 1.55 A | x-ray diffraction | A, B | — | — |
| 3KL1 | Crystal structure of abscisic acid receptor PYL2 at 1.55 a | x-ray diffraction | A, B | — | — |
| 3NJ0 | X-ray crystal structure of the PYL2-pyrabactin A complex | x-ray diffraction | A, B, C | — | — |
| 3NJ0 | X-ray crystal structure of the PYL2-pyrabactin a complex | x-ray diffraction | A, B, C | — | — |
| 3NJ1 | X-ray crystal structure of the PYL2(V114I)-pyrabactin A complex | x-ray diffraction | A | — | — |
| 3NJ1 | X-ray crystal structure of the PYL2(V114I)-pyrabactin a complex | x-ray diffraction | A | — | — |
| 3NMH | Crystal structure of the abscisic receptor PYL2 in complex with pyrabactin | x-ray diffraction | A, B, C | — | — |
| 3NMH | Crystal structure of the abscisic receptor PYL2 in complex with pyrabactin | x-ray diffraction | A, B, C | — | — |
| 3NMP | Crystal structure of the abscisic receptor PYL2 mutant A93F in complex with pyrabactin | x-ray diffraction | A, B, C | — | — |
| 3NMP | Crystal structure of the abscisic receptor PYL2 mutant A93F in complex with pyrabactin | x-ray diffraction | A, B, C | — | — |
| 3NMT | Crystal structure of pyrabactin bound abscisic acid receptor PYL2 mutant A93F in complex with type… | x-ray diffraction | A | — | — |
| 3NMT | Crystal structure of pyrabactin bound abscisic acid receptor PYL2 mutant A93F in complex with type… | x-ray diffraction | A | — | — |
| 3NMV | Crystal structure of pyrabactin-bound abscisic acid receptor PYL2 mutant A93F in complex with type… | x-ray diffraction | A | — | — |
| 3NMV | Crystal structure of pyrabactin-bound abscisic acid receptor PYL2 mutant A93F in complex with type… | x-ray diffraction | A | — | — |
| 3NR4 | Pyrabactin-bound PYL2 | x-ray diffraction | A, B, C | — | — |
| 3NR4 | Pyrabactin-bound PYL2 | x-ray diffraction | A, B, C | — | — |
| 3NS2 | High-resolution structure of pyrabactin-bound PYL2 | x-ray diffraction | A, B, C | — | — |
| 3NS2 | High-resolution structure of pyrabactin-bound PYL2 | x-ray diffraction | A, B, C | — | — |
| 3UJL | Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2 | x-ray diffraction | A | — | — |
| 3UJL | Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2 | x-ray diffraction | A | — | — |
| 4LA7 | X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex | x-ray diffraction | A | — | — |
| 4LA7 | X-ray crystal structure of the PYL2-quinabactin-HAB1 ternary complex | x-ray diffraction | A | — | — |
| 4LG5 | ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | — | — |
| 4LG5 | Aba-mimicking ligand quinabactin in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | — | — |
| 4LGA | ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE… | x-ray diffraction | A | — | — |
| 4LGA | Aba-mimicking ligand N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6- yl)-1-phenylmethanesulfonamide… | x-ray diffraction | A | — | — |
| 4LGB | ABA-mimicking ligand N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-(4-METHYLPHENYL)METHANESUL… | x-ray diffraction | A | — | — |
| 4LGB | Aba-mimicking ligand N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6… | x-ray diffraction | A | — | — |
| 5JNN | Crystal structure of abscisic acid receptor PYL2 in complex with Phaseic acid. | x-ray diffraction | A | 6LM | 1 (best 0.82) |
| 5JNN | Crystal structure of abscisic acid receptor PYL2 in complex with phaseic acid. | x-ray diffraction | A | — | — |
| 5VR7 | ABA-mimicking ligand AMF1alpha in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A1F | — |
| 5VR7 | Aba-mimicking ligand AMF1ALPHA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A1F | — |
| 5VRO | ABA-mimicking ligand AMF1beta in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A7S | 3 (best 0.86) |
| 5VRO | Aba-mimicking ligand AMF1BETA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A7S | — |
| 5VS5 | ABA-mimicking ligand AMF2alpha in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | 9J7 | 3 (best 0.85) |
| 5VS5 | Aba-mimicking ligand AMF2ALPHA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | 9J7 | — |
| 5VSQ | ABA-mimicking ligand AMF2beta in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A2V | — |
| 5VSQ | Aba-mimicking ligand AMF2BETA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A2V | — |
| 5VSR | ABA-mimicking ligand AMF4 in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | AF0 | 4 (best 0.86) |
| 5VSR | Aba-mimicking ligand AMF4 in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | AF0 | — |
| 5VT7 | ABA-mimicking ligand AMC1beta in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A1C | 3 (best 0.86) |
| 5VT7 | Aba-mimicking ligand AMC1BETA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | A | A1C | — |
| 7MWN | An engineered PYL2-based WIN 55,212-2 synthetic cannabinoid sensor with a stabilized HAB1 variant | x-ray diffraction | A | WI5 | 3 (best 0.86) |
| 7MWN | An engineered PYL2-based win 55,212-2 synthetic cannabinoid sensor with a stabilized HAB1 variant | x-ray diffraction | A | WI5 | — |
| O80992 | AlphaFold monomer V2.0 prediction for abscisic acid receptor PYL2 (O80992) | predicted | A | — | 2 (best 0.77) |
Ligands
- 9J7 · 1-(2,3-difluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2, 3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 2 records
- A1C · 1-(3-chloro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 2 records
- A1F · 1-(2-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 2 records
- A2V · 1-(3,5-difluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2, 3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 2 records
- A7S · 1-(3-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 2 records
- AF0 · N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-(2,3,5,6-tetrafluoro-4-methylphenyl)methanesulfonamide · in 2 records
- WI5 · {(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone · in 2 records
- 6LM · (3S,4E)-5-[(1R,5R,8S)-8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo[3.2.1]octan-8-yl]-3-methylpent-4-enoic acid · in 1 record
Experiment against prediction
- 7MWN chain A against the predicted model O80992: TM-score 0.98, RMSD 0.91 Å
- 7MWN chain A against the predicted model O80992: TM-score 0.98, RMSD 0.91 Å
- 4LA7 chain A against the predicted model O80992: TM-score 0.98, RMSD 0.98 Å
- 4LA7 chain A against the predicted model O80992: TM-score 0.98, RMSD 0.98 Å
- 3KDI chain A against the predicted model O80992: TM-score 0.97, RMSD 1.01 Å
- 3KDI chain A against the predicted model O80992: TM-score 0.97, RMSD 1.01 Å
- 5VT7 chain A against the predicted model O80992: TM-score 0.97, RMSD 1.00 Å
- 5VT7 chain A against the predicted model O80992: TM-score 0.97, RMSD 1.00 Å
- 5VSR chain A against the predicted model O80992: TM-score 0.97, RMSD 1.01 Å
- 5VSR chain A against the predicted model O80992: TM-score 0.97, RMSD 1.01 Å
Elsewhere
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