UniProt O79881
NADH-ubiquinone oxidoreductase chain 4 (O79881)
NADH-ubiquinone oxidoreductase chain 4 (UniProt O79881), EC 1.6.5.3, 7.1.1.2: 20 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 137 pockets. Binding sites, druggability and experiment against…
- UniProt
- O79881
- Protein
- NADH-ubiquinone oxidoreductase chain 4
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 137 · 21 records with a druggable one
Structures
21 records of O79881 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPN | Architecture of mammalian respirasome | electron microscopy | h | — | 4 (best 0.84) |
| 5GUP | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | electron microscopy | q | PEE, CDL | 4 (best 0.86) |
| 8UD1 | High resolution in-situ structure of complex I in respiratory supercomplex (composite) | electron microscopy | 1M | 3PE, CDL, PC1 | 8 (best 0.86) |
| 8UEO | In-situ complex I (Active-Apo) | electron microscopy | 1M | 3PE, CDL, PC1 | 7 (best 0.86) |
| 8UEP | In-situ complex I, Active-Q10 (State-alpha) | electron microscopy | 1M | PC1, 3PE | 8 (best 0.84) |
| 8UEQ | In-situ complex I with Q10 (State-beta) | electron microscopy | 1M | 3PE | 7 (best 0.85) |
| 8UER | In-situ complex I with Q10 (State-gamma) | electron microscopy | 1M | 3PE, PC1 | 7 (best 0.87) |
| 8UES | In-situ complex I, Deactive class01 | electron microscopy | 1M | 3PE, PC1, PGT | 8 (best 0.84) |
| 8UET | In-situ complex I, Deactive class02 | electron microscopy | 1M | 3PE, PGT, PC1 | 8 (best 0.86) |
| 8UEU | In-situ complex I, Deactive class03 | electron microscopy | 1M | 3PE, PGT, PC1 | 7 (best 0.85) |
| 8UEV | In-situ complex I, Deactive class04 | electron microscopy | 1M | 3PE, PC1, PGT | 8 (best 0.86) |
| 8UEW | In-situ complex I, Deactive class05 | electron microscopy | 1M | 3PE, PC1, PGT | 7 (best 0.86) |
| 8UEX | In-situ complex I, Deactive class06 | electron microscopy | 1M | 3PE, PC1, PGT | 8 (best 0.87) |
| 8UEY | In-situ complex I, Deactive class07 | electron microscopy | 1M | 3PE, PC1, PGT | 8 (best 0.87) |
| 8UEZ | In-situ complex I, Active-Q10 (State-delta) | electron microscopy | 1M | PC1, 3PE | 7 (best 0.84) |
| 8UGH | In-situ structure of typeA supercomplex with lipids in respiratory chain (composite) | electron microscopy | 1M | 3PE, CDL, PC1, PGT | 6 (best 0.85) |
| 8UGI | High resolution in-situ structure of typeA supercomplex in respiratory chain (I1III2IV1,composite) | electron microscopy | 1M | 3PE, CDL, PC1 | 5 (best 0.87) |
| 8UGJ | In-situ structure of typeB supercomplex in respiratory chain (composite) | electron microscopy | 1M | 3PE, CDL, PC1 | 6 (best 0.86) |
| 8UGN | In-situ structure of typeO supercomplex in respiratory chain (composite) | electron microscopy | 1M, 5M | 3PE, CDL, PC1 | 5 (best 0.86) |
| 8UGR | In-situ structure of typeX supercomplex in respiratory chain (composite) | electron microscopy | 1M, 5M | 3PE, CDL, PC1 | 5 (best 0.87) |
| O79881 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 4 (O79881) | predicted | A | — | 4 (best 0.60) |
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 18 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 17 records
- CDL · Cardiolipin · in 8 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 8 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
Experiment against prediction
- 8UD1 chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.34 Å
- 8UGI chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.36 Å
- 8UGJ chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.37 Å
- 8UGN chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.37 Å
- 8UGH chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.39 Å
- 8UGR chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.45 Å
- 8UEW chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.49 Å
- 8UES chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.50 Å
- 8UEV chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.51 Å
- 8UEY chain 1M against the predicted model O79881: TM-score 1.00, RMSD 0.51 Å
Elsewhere
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