UniProt O75923
Isoform 6 of Dysferlin (O75923)
Isoform 6 of Dysferlin (UniProt O75923): 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75923
- Protein
- Isoform 6 of Dysferlin
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 45 · 3 records with a druggable one
Structures
17 records of O75923 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CAH | Structure of inner DysF domain of human dysferlin | x-ray diffraction | B | — | — |
| 4CAH | Structure of inner dysf domain of human dysferlin | x-ray diffraction | B | — | — |
| 4CAI | Structure of inner DysF domain of human dysferlin | x-ray diffraction | A, B, C | — | — |
| 4CAI | Structure of inner dysf domain of human dysferlin | x-ray diffraction | A, B, C | — | — |
| 4IHB | X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4IHB | X-ray structure of the canonical C2A domain from human dysferlin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4IQH | Crystal Structure Analysis of Dysferlin C2A variant 1 (C2Av1) | x-ray diffraction | A, B, C | — | — |
| 4IQH | Crystal structure analysis of dysferlin C2A variant 1 (C2AV1) | x-ray diffraction | A, B, C | — | — |
| 7JOF | Calcium-bound C2A Domain from Human Dysferlin | x-ray diffraction | A, B, C, D | CA | 4 (best 0.70) |
| 7JOF | Calcium-bound C2A domain from human dysferlin | x-ray diffraction | A, B, C, D | CA | — |
| 7K6B | Solution Structure of the Dysferlin C2A Domain in its Calcium-free State | solution nmr | A | — | 1 (best 0.26) |
| 7K6B | Solution structure of the dysferlin C2A domain in its calcium-free state | solution nmr | A | — | — |
| 7KRB | Solution Structure of the Dysferlin C2A Domain in its Calcium-bound State | solution nmr | A | — | — |
| 7KRB | Solution structure of the dysferlin C2A domain in its calcium-bound state | solution nmr | A | — | — |
| 9B8K | Cryo-EM structure of human dysferlin monomer | electron microscopy | A | — | 20 (best 0.78) |
| 9B8L | Cryo-EM structure of human dysferlin dimer | electron microscopy | A, B | — | 20 (best 0.87) |
| O75923 | AlphaFold monomer V2.0 prediction for dysferlin (O75923) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 2 records
Experiment against prediction
- 7JOF chain A against the predicted model O75923: TM-score 0.95, RMSD 0.78 Å
- 7JOF chain A against the predicted model O75923: TM-score 0.95, RMSD 0.78 Å
- 7JOF chain C against the predicted model O75923: TM-score 0.95, RMSD 0.80 Å
- 7JOF chain C against the predicted model O75923: TM-score 0.95, RMSD 0.80 Å
- 4IQH chain B against the predicted model O75923: TM-score 0.94, RMSD 0.90 Å
- 4IQH chain B against the predicted model O75923: TM-score 0.94, RMSD 0.90 Å
- 4IHB chain B against the predicted model O75923: TM-score 0.93, RMSD 1.29 Å
- 4IHB chain B against the predicted model O75923: TM-score 0.93, RMSD 1.29 Å
- 4IQH chain A against the predicted model O75923: TM-score 0.93, RMSD 0.91 Å
- 4IQH chain A against the predicted model O75923: TM-score 0.93, RMSD 0.91 Å
Elsewhere
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