UniProt O75317
Ubiquitin carboxyl-terminal hydrolase 12 (O75317)
Ubiquitin carboxyl-terminal hydrolase 12 (UniProt O75317), EC 3.4.19.12: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O75317
- Protein
- Ubiquitin carboxyl-terminal hydrolase 12
- EC
- 3.4.19.12
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 30 · 4 records with a druggable one
Structures
11 records of O75317 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5K16 | Crystal structure of free Ubiquitin-specific protease 12 | x-ray diffraction | A, B | ZN | 5 (best 0.76) |
| 5K16 | Crystal structure of free ubiquitin-specific protease 12 | x-ray diffraction | A, B | ZN | — |
| 5K1A | Crystal structure of the UAF1-USP12 complex in C2 space group | x-ray diffraction | A, C, E, G | ZN | — |
| 5K1A | Crystal structure of the UAF1-USP12 complex in C2 space group | x-ray diffraction | A, C, E, G | ZN | — |
| 5K1B | Crystal structure of the UAF1/USP12 complex in F222 space group | x-ray diffraction | A | ZN | 5 (best 0.80) |
| 5K1B | Crystal structure of the UAF1/USP12 complex in F222 space group | x-ray diffraction | A | ZN | — |
| 5K1C | Crystal structure of the UAF1/WDR20/USP12 complex | x-ray diffraction | A | ZN | 6 (best 0.83) |
| 5K1C | Crystal structure of the UAF1/WDR20/USP12 complex | x-ray diffraction | A | ZN | — |
| 5L8W | Structure of USP12-UB-PRG/UAF1 | x-ray diffraction | A | AYE, ZN | 8 (best 0.81) |
| 5L8W | Structure of USP12-ub-PRG/UAF1 | x-ray diffraction | A | AYE, ZN | — |
| O75317 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 12 (O75317) | predicted | A | — | 6 (best 0.46) |
Ligands
Experiment against prediction
- 5K16 chain A against the predicted model O75317: TM-score 0.98, RMSD 1.04 Å
- 5K16 chain A against the predicted model O75317: TM-score 0.98, RMSD 1.04 Å
- 5L8W chain A against the predicted model O75317: TM-score 0.98, RMSD 1.22 Å
- 5L8W chain A against the predicted model O75317: TM-score 0.98, RMSD 1.22 Å
- 5K1C chain A against the predicted model O75317: TM-score 0.93, RMSD 2.13 Å
- 5K1C chain A against the predicted model O75317: TM-score 0.93, RMSD 2.13 Å
- 5K16 chain B against the predicted model O75317: TM-score 0.92, RMSD 2.42 Å
- 5K16 chain B against the predicted model O75317: TM-score 0.92, RMSD 2.42 Å
- 5K1B chain A against the predicted model O75317: TM-score 0.91, RMSD 2.08 Å
- 5K1B chain A against the predicted model O75317: TM-score 0.91, RMSD 2.08 Å
Elsewhere
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