UniProt O75306
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (O75306)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (UniProt O75306), EC 1.6.5.3, 1.6.99.3: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 25 pockets. Binding sites, druggability…
- UniProt
- O75306
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 25 · 5 records with a druggable one
Structures
9 records of O75306 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5XTB | Cryo-EM structure of human respiratory complex I matrix arm | electron microscopy | Q | SF4 | 7 (best 0.89) |
| 5XTB | Cryo-EM structure of human respiratory complex I matrix arm | electron microscopy | Q | SF4 | — |
| 5XTC | Cryo-EM structure of human respiratory complex I transmembrane arm | electron microscopy | Q | PEE | 4 (best 0.79) |
| 5XTC | Cryo-EM structure of human respiratory complex I transmembrane arm | electron microscopy | Q | PEE | — |
| 5XTD | Cryo-EM structure of human respiratory complex I | electron microscopy | Q | PLX, SF4, PEE | 5 (best 0.88) |
| 5XTD | Cryo-EM structure of human respiratory complex I | electron microscopy | Q | PLX, SF4, PEE | — |
| 5XTH | Cryo-EM structure of human respiratory supercomplex I1III2IV1 | electron microscopy | Q | PLX, SF4, PEE | 3 (best 0.89) |
| 5XTI | Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 | electron microscopy | Q, BQ | PLX, SF4, PEE | 4 (best 0.89) |
| O75306 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 2… | predicted | A | — | 2 (best 0.31) |
Ligands
Experiment against prediction
- 5XTB chain Q against the predicted model O75306: TM-score 0.98, RMSD 0.92 Å
- 5XTB chain Q against the predicted model O75306: TM-score 0.98, RMSD 0.92 Å
- 5XTI chain Q against the predicted model O75306: TM-score 0.97, RMSD 1.39 Å
- 5XTI chain BQ against the predicted model O75306: TM-score 0.97, RMSD 1.39 Å
- 5XTH chain Q against the predicted model O75306: TM-score 0.97, RMSD 1.39 Å
- 5XTD chain Q against the predicted model O75306: TM-score 0.97, RMSD 1.45 Å
- 5XTD chain Q against the predicted model O75306: TM-score 0.97, RMSD 1.45 Å
- 5XTC chain Q against the predicted model O75306: TM-score 0.67, RMSD 1.84 Å
- 5XTC chain Q against the predicted model O75306: TM-score 0.67, RMSD 1.84 Å
Elsewhere
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