UniProt O75144
ICOS ligand (O75144)
ICOS ligand (UniProt O75144): 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75144
- Protein
- ICOS ligand
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 15 · 1 record with a druggable one
Structures
5 records of O75144 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6X4G | Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain | x-ray diffraction | C | NAG, BMA, MAN | 2 (best 0.41) |
| 6X4G | Crystal structure of icos in complex with icos-L and an anti icos-L vnar domain | x-ray diffraction | C | NAG, BMA, MAN | — |
| 6X4T | Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain | x-ray diffraction | A, C | NAG | 12 (best 0.67) |
| 6X4T | Crystal structure of icos-L in complex with prezalumab and vnar domain | x-ray diffraction | A, C | NAG | — |
| O75144 | AlphaFold monomer V2.0 prediction for icos ligand (O75144) | predicted | A | — | 1 (best 0.36) |
Ligands
Experiment against prediction
- 6X4T chain C against the predicted model O75144: TM-score 0.93, RMSD 1.52 Å
- 6X4T chain C against the predicted model O75144: TM-score 0.93, RMSD 1.52 Å
- 6X4G chain C against the predicted model O75144: TM-score 0.93, RMSD 1.55 Å
- 6X4G chain C against the predicted model O75144: TM-score 0.93, RMSD 1.55 Å
- 6X4T chain A against the predicted model O75144: TM-score 0.93, RMSD 1.64 Å
- 6X4T chain A against the predicted model O75144: TM-score 0.93, RMSD 1.64 Å
Elsewhere
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