UniProt O67518
DNA mismatch repair protein MutL (O67518)
DNA mismatch repair protein MutL (UniProt O67518): 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O67518
- Protein
- DNA mismatch repair protein MutL
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 5 · 1 record with a druggable one
Structures
10 records of O67518 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5B42 | Crystal structure of the C-terminal endonuclease domain of Aquifex aeolicus MutL. | x-ray diffraction | A | — | — |
| 5B42 | Crystal structure of the C-terminal endonuclease domain of aquifex aeolicus mutl. | x-ray diffraction | A | — | — |
| 5X9Y | Crystal structure of the ATPase domain from bacterial mismatch repair endonuclease aquifex aeolicus… | x-ray diffraction | C, A, B | — | — |
| 5Z41 | Aquifex aeolicus mutl endonuclease domain with a single zinc ion. | x-ray diffraction | A | ZN, MG | — |
| 5Z42 | Aquifex aeolicus mutl endonuclease domain with three zinc ions. | x-ray diffraction | A | ZN, NA, CL, MG | — |
| 6LZI | Aquifex aeolicus MutL ATPase domain complexed with ADP | x-ray diffraction | A | MG, ADP | 2 (best 0.43) |
| 6LZI | Aquifex aeolicus mutl ATPase domain complexed with ADP | x-ray diffraction | A | MG, ADP | — |
| 6LZJ | Aquifex aeolicus mutl ATPase domain complexed with amppcp | x-ray diffraction | A | MG, ACP | — |
| 6LZK | Aquifex aeolicus mutl ATPase domain with K252N mutation | x-ray diffraction | A, B, C | NA | — |
| O67518 | AlphaFold monomer V2.0 prediction for DNA mismatch repair protein mutl (O67518) | predicted | A | — | 3 (best 0.76) |
Ligands
Experiment against prediction
- 6LZK chain A against the predicted model O67518: TM-score 0.98, RMSD 0.91 Å
- 5X9Y chain C against the predicted model O67518: TM-score 0.98, RMSD 0.94 Å
- 6LZJ chain A against the predicted model O67518: TM-score 0.98, RMSD 0.80 Å
- 6LZI chain A against the predicted model O67518: TM-score 0.97, RMSD 0.79 Å
- 6LZI chain A against the predicted model O67518: TM-score 0.97, RMSD 0.79 Å
- 6LZK chain C against the predicted model O67518: TM-score 0.97, RMSD 1.05 Å
- 5B42 chain A against the predicted model O67518: TM-score 0.96, RMSD 0.97 Å
- 5B42 chain A against the predicted model O67518: TM-score 0.96, RMSD 0.97 Å
- 5Z42 chain A against the predicted model O67518: TM-score 0.95, RMSD 0.91 Å
- 5Z41 chain A against the predicted model O67518: TM-score 0.89, RMSD 1.85 Å
Elsewhere
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