UniProt O66990
Dihydroorotase (O66990)
Dihydroorotase (UniProt O66990), EC 3.5.2.3: 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O66990
- Protein
- Dihydroorotase
- EC
- 3.5.2.3
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 4 · 3 records with a druggable one
Structures
15 records of O66990 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XRF | The Crystal Structure of a Novel, Latent Dihydroorotase from Aquifex aeolicus at 1.7 A resolution | x-ray diffraction | A | — | — |
| 1XRF | The crystal structure of a novel, latent dihydroorotase from aquifex aeolicus at 1.7 a resolution | x-ray diffraction | A | — | — |
| 1XRT | The Crystal Structure of a Novel, Latent Dihydroorotase from Aquifex Aeolicus at 1.7 A Resolution | x-ray diffraction | A, B | — | — |
| 1XRT | The crystal structure of a novel, latent dihydroorotase from aquifex aeolicus at 1.7 a resolution | x-ray diffraction | A, B | — | — |
| 3D6N | Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase | x-ray diffraction | A | — | — |
| 3D6N | Crystal structure of aquifex dihydroorotase activated by aspartate transcarbamoylase | x-ray diffraction | A | — | — |
| 4BJH | Crystal Structure of the Aquifex Reactor Complex Formed by Dihydroorotase (H180A, H232A) with… | x-ray diffraction | A | — | — |
| 4BJH | Crystal structure of the aquifex reactor complex formed by dihydroorotase (H180A, H232A) with… | x-ray diffraction | A | — | — |
| 6GDD | Dihydroorotase from aquifex aeolicus under 1200 bar of hydrostatic pressure | x-ray diffraction | A | ZN, SO4 | 1 (best 0.58) |
| 6GDD | Dihydroorotase from aquifex aeolicus under 1200 bar of hydrostatic pressure | x-ray diffraction | A | ZN, SO4 | — |
| 6GDE | Dihydroorotase from aquifex aeolicus standard (P,T) | x-ray diffraction | A | ZN | 1 (best 0.53) |
| 6GDE | Dihydroorotase from aquifex aeolicus standard (P,T) | x-ray diffraction | A | ZN | — |
| 6GDF | Dihydroorotase from aquifex aeolicus under 600 bar of hydrostatic pressure | x-ray diffraction | A | ZN, SO4 | 1 (best 0.53) |
| 6GDF | Dihydroorotase from aquifex aeolicus under 600 bar of hydrostatic pressure | x-ray diffraction | A | ZN, SO4 | — |
| O66990 | AlphaFold monomer V2.0 prediction for dihydroorotase (O66990) | predicted | A | — | 1 (best 0.45) |
Ligands
Experiment against prediction
- 4BJH chain A against the predicted model O66990: TM-score 1.00, RMSD 0.20 Å
- 4BJH chain A against the predicted model O66990: TM-score 1.00, RMSD 0.20 Å
- 3D6N chain A against the predicted model O66990: TM-score 1.00, RMSD 0.35 Å
- 3D6N chain A against the predicted model O66990: TM-score 1.00, RMSD 0.35 Å
- 1XRF chain A against the predicted model O66990: TM-score 0.98, RMSD 0.86 Å
- 1XRF chain A against the predicted model O66990: TM-score 0.98, RMSD 0.86 Å
- 6GDF chain A against the predicted model O66990: TM-score 0.98, RMSD 0.91 Å
- 6GDF chain A against the predicted model O66990: TM-score 0.98, RMSD 0.91 Å
- 6GDE chain A against the predicted model O66990: TM-score 0.98, RMSD 0.91 Å
- 6GDE chain A against the predicted model O66990: TM-score 0.98, RMSD 0.91 Å
Elsewhere
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