UniProt O66841
NADH-quinone oxidoreductase subunit F (O66841)
NADH-quinone oxidoreductase subunit F (UniProt O66841), EC 1.6.5.11, 7.1.1.-: 35 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 146 pockets. Binding sites, druggability and experiment against…
- UniProt
- O66841
- Protein
- NADH-quinone oxidoreductase subunit F
- EC
- 1.6.5.11, 7.1.1.-
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 146 · 15 records with a druggable one
Structures
36 records of O66841 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HL2 | wild-type NuoEF from Aquifex aeolicus - oxidized form | x-ray diffraction | B, D | SF4, FMN, NA, SO4, CL | — |
| 6HL2 | Wild-type nuoef from aquifex aeolicus - oxidized form | x-ray diffraction | B, D | SF4, FMN, NA, SO4, CL | — |
| 6HL3 | wild-type NuoEF from Aquifex aeolicus - oxidized form bound to NAD+ | x-ray diffraction | B, D | SF4, FMN, NAD, CL, NA, SO4 | — |
| 6HL3 | Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+ | x-ray diffraction | B, D | SF4, FMN, NAD, CL, NA, SO4 | — |
| 6HL4 | wild-type NuoEF from Aquifex aeolicus - reduced form | x-ray diffraction | B, D | SF4, FMN, CL | — |
| 6HL4 | Wild-type nuoef from aquifex aeolicus - reduced form | x-ray diffraction | B, D | SF4, FMN, CL | — |
| 6HLA | wild-type NuoEF from Aquifex aeolicus - reduced form bound to NADH | x-ray diffraction | B, D | SF4, FMN, NAD, NA | — |
| 6HLA | Wild-type nuoef from aquifex aeolicus - reduced form bound to NADH | x-ray diffraction | B, D | SF4, FMN, NAD, NA | — |
| 6HLI | wild-type NuoEF from Aquifex aeolicus - reduced form bound to NAD+ | x-ray diffraction | B, D | SF4, FMN, NAD | — |
| 6HLI | Wild-type nuoef from aquifex aeolicus - reduced form bound to NAD+ | x-ray diffraction | B, D | SF4, FMN, NAD | — |
| 6HLJ | Variant G129S of NuoEF from Aquifex aeolicus - oxidized from | x-ray diffraction | B, D | SF4, FMN, NA | — |
| 6HLJ | Variant G129S of nuoef from aquifex aeolicus - oxidized from | x-ray diffraction | B, D | SF4, FMN, NA | — |
| 6HLM | Variant G129D of NuoEF from Aquifex aeolicus bound to NAD+ | x-ray diffraction | B, D | SF4, FMN, NAD, NA | — |
| 6HLM | Variant G129D of nuoef from aquifex aeolicus bound to NAD+ | x-ray diffraction | B, D | SF4, FMN, NAD, NA | — |
| 6Q9C | Crystal structure of Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE and NuoF bound to NADH… | x-ray diffraction | B, D | FES, SF4, FMN, NAI, NA, SO4 | 11 (best 0.77) |
| 6Q9C | Crystal structure of aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe and nuof bound to… | x-ray diffraction | B, D | SF4, FMN, NAI, NA, SO4 | — |
| 6Q9G | Crystal structure of reduced Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE G129D and NuoF… | x-ray diffraction | B, D | SF4, FMN, NAI, NA, SO4 | — |
| 6Q9G | Crystal structure of reduced aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe G129D and… | x-ray diffraction | B, D | SF4, FMN, NAI, NA, SO4 | — |
| 6Q9J | Crystal structure of reduced aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe G129S and… | x-ray diffraction | B, D | SF4, FMN, NAI, NA, SO4 | — |
| 6Q9K | Crystal structure of reduced aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe and nuof… | x-ray diffraction | B, D | SF4, FMN, NAI, NA, SO4 | — |
| 6R7P | Crystal structure of oxidized Aquifex aeolicus NADH-qui oxidoreductase subunits NuoE and NuoF S96M | x-ray diffraction | B, D | FES, SF4, FMN, SO4, CL, NA | 11 (best 0.75) |
| 6R7P | Crystal structure of oxidized aquifex aeolicus NADH-quinone oxidoreductase subunits nuoe and nuof… | x-ray diffraction | B, D | SF4, FMN, SO4, NA, CL | — |
| 6SAQ | wild-type NuoEF from Aquifex aeolicus bound to NADH-OH | x-ray diffraction | B, D | FES, FMN, SF4, L3W | 9 (best 0.78) |
| 6SAQ | Wild-type nuoef from aquifex aeolicus bound to NADH-oh | x-ray diffraction | B, D | FMN, SF4, L3W | — |
| 8QG1 | Crystal structure of oxidized respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | B, D | FES, SF4, FMN, APR, SO4, NA | 10 (best 0.76) |
| 8QGW | Crystal structure of oxidized respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | B, D | FES, SF4, FMN, A3D, CL, NA | 10 (best 0.77) |
| 8QH4 | Crystal structure of reduced respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to… | x-ray diffraction | B, D | FES, SF4, FNR, A3D, SO4, NA | 10 (best 0.76) |
| 8QH7 | Crystal structure of respiratory Complex I subunits NuoEF from Aquifex aeolicus bound to reduced… | x-ray diffraction | B, D | FES, NA, SF4, FNR, AP0, SO4 | 10 (best 0.77) |
| 9FDJ | Crystal structure of the NuoEF variant R66G (NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | B, D | FES, SO4, SF4, FMN, NAI, CL | 10 (best 0.75) |
| 9FE0 | Crystal Structure of reduced NuoEF variant R66G(NuoF) from Aquifex aeolicus bound to NAD+ | x-ray diffraction | B, D | FES, SO4, SF4, FNR, NAD, CL | 11 (best 0.76) |
| 9FE7 | Crystal Structure of oxidized NuoEF variant P228R(NuoF) from Aquifex aeolicus | x-ray diffraction | B, D | FES, NA, SF4, FMN, CL | 9 (best 0.75) |
| 9FEA | Crystal Structure of reduced NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NAD+ | x-ray diffraction | B, D | FES, SF4, FNR, NAD, NA, SO4 | 10 (best 0.76) |
| 9FIF | Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | B, D | FES, SF4, FMN, NAI, NA, SO4 | 10 (best 0.76) |
| 9FIH | Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic… | x-ray diffraction | B, D | FES, SF4, FNR, NAI, NA | 9 (best 0.76) |
| 9FII | Crystal Structure of oxidized NuoEF variant E222K(NuoF) from Aquifex aeolicus | x-ray diffraction | B, D | FES, NA, SF4, FMN, CL | 12 (best 0.74) |
| O66841 | AlphaFold monomer V2.0 prediction for NADH-quinone oxidoreductase subunit F (O66841) | predicted | A | — | 4 (best 0.74) |
Ligands
- SF4 · Iron/sulfur cluster · in 35 records
- FMN · Flavin mononucleotide · in 30 records
- NA · Sodium ion · in 29 records
- SO4 · Sulfate ion · in 20 records
- FES · Fe2/s2 (inorganic) cluster · in 14 records
- CL · Chloride ion · in 13 records
- NAD · Nicotinamide-adenine-dinucleotide · in 10 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 9 records
- FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol · in 5 records
- A3D · 3-acetylpyridine adenine dinucleotide · in 2 records
- L3W · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[[(1~{E},3~{Z})-5-azanyl-4-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-methanoyl-amino]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate · in 2 records
- AP0 · Acetyl pyridine adenine dinucleotide, reduced · in 1 record
- APR · Adenosine-5-diphosphoribose · in 1 record
- K · Potassium ion · in 1 record
Experiment against prediction
- 6Q9K chain B against the predicted model O66841: TM-score 1.00, RMSD 0.20 Å
- 6Q9C chain B against the predicted model O66841: TM-score 1.00, RMSD 0.21 Å
- 6Q9C chain B against the predicted model O66841: TM-score 1.00, RMSD 0.21 Å
- 6Q9G chain B against the predicted model O66841: TM-score 1.00, RMSD 0.22 Å
- 6Q9G chain B against the predicted model O66841: TM-score 1.00, RMSD 0.22 Å
- 9FIH chain D against the predicted model O66841: TM-score 1.00, RMSD 0.23 Å
- 6Q9J chain B against the predicted model O66841: TM-score 1.00, RMSD 0.23 Å
- 8QH7 chain B against the predicted model O66841: TM-score 1.00, RMSD 0.23 Å
- 6Q9C chain D against the predicted model O66841: TM-score 1.00, RMSD 0.24 Å
- 8QG1 chain B against the predicted model O66841: TM-score 1.00, RMSD 0.26 Å
Elsewhere
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