UniProt O60942
mRNA-capping enzyme (O60942)
mRNA-capping enzyme (UniProt O60942), EC 2.7.7.50, 3.6.1.74: 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O60942
- Protein
- mRNA-capping enzyme
- EC
- 2.7.7.50, 3.6.1.74
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 7 records with a druggable one
Structures
12 records of O60942 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2C46 | CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase | x-ray diffraction | A, B, C, D | — | — |
| 2C46 | Crystal structure of the human RNA guanylyltransferase and 5'- phosphatase | x-ray diffraction | A, B, C, D | — | — |
| 3S24 | Crystal structure of human mRNA guanylyltransferase | x-ray diffraction | A, B, C, D, E, G, F | — | — |
| 3S24 | Crystal structure of human mRNA guanylyltransferase | x-ray diffraction | A, B, C, D, E, G, F | — | — |
| 8P4A | Structural insights into human co-transcriptional capping - structure 1 | electron microscopy | M | — | 2 (best 0.79) |
| 8P4B | Structural insights into human co-transcriptional capping - structure 2 | electron microscopy | M | — | 2 (best 0.78) |
| 8P4C | Structural insights into human co-transcriptional capping - structure 3 | electron microscopy | M | — | 2 (best 0.77) |
| 8P4D | Structural insights into human co-transcriptional capping - structure 4 | electron microscopy | M | — | 1 (best 0.78) |
| 8P4E | Structural insights into human co-transcriptional capping - structure 5 | electron microscopy | M | — | 2 (best 0.74) |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | a | GTP | 1 (best 0.77) |
| 8W8F | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | electron microscopy | a | GTP | 1 (best 0.75) |
| O60942 | AlphaFold monomer V2.0 prediction for mRNA-capping enzyme (O60942) | predicted | A | — | — |
Ligands
- GTP · Guanosine-5'-triphosphate · in 2 records
Experiment against prediction
- 8P4E chain M against the predicted model O60942: TM-score 0.98, RMSD 1.01 Å
- 3S24 chain E against the predicted model O60942: TM-score 0.98, RMSD 1.05 Å
- 3S24 chain E against the predicted model O60942: TM-score 0.98, RMSD 1.05 Å
- 3S24 chain C against the predicted model O60942: TM-score 0.97, RMSD 1.28 Å
- 3S24 chain C against the predicted model O60942: TM-score 0.97, RMSD 1.28 Å
- 2C46 chain D against the predicted model O60942: TM-score 0.96, RMSD 1.16 Å
- 2C46 chain D against the predicted model O60942: TM-score 0.96, RMSD 1.16 Å
- 8P4B chain M against the predicted model O60942: TM-score 0.96, RMSD 1.60 Å
- 2C46 chain B against the predicted model O60942: TM-score 0.94, RMSD 1.10 Å
- 2C46 chain B against the predicted model O60942: TM-score 0.94, RMSD 1.10 Å
Elsewhere
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