UniProt O60678
Protein arginine N-methyltransferase 3 (O60678)
Protein arginine N-methyltransferase 3 (UniProt O60678), EC 2.1.1.319: 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O60678
- Protein
- Protein arginine N-methyltransferase 3
- EC
- 2.1.1.319
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 15 · 5 records with a druggable one
Structures
10 records of O60678 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FYT | Human HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) protein | x-ray diffraction | A | — | — |
| 2FYT | Human HMT1 hnrnp methyltransferase-like 3 (S. cerevisiae) protein | x-ray diffraction | A | — | — |
| 3SMQ | Crystal structure of protein arginine methyltransferase 3 | x-ray diffraction | A | — | — |
| 3SMQ | Crystal structure of protein arginine methyltransferase 3 | x-ray diffraction | A | — | — |
| 8G2F | Crystal Structure of PRMT3 with Compound II710 | x-ray diffraction | A | DVS | 3 (best 0.62) |
| 8G2G | Crystal structure of PRMT3 with compound YD1113 | x-ray diffraction | A, B | YVU, SO4 | 4 (best 0.77) |
| 8SHB | Crystal Structure of PRMT3 with Compound YD1-208 | x-ray diffraction | A | GV3 | 2 (best 0.60) |
| 8SHR | Crystal Structure of PRMT3 with Compound YD1-214 | x-ray diffraction | A | HIY | 1 (best 0.75) |
| 8SIO | Crystal structure of PRMT3 with YD1-66 | x-ray diffraction | A, B | GXF | 5 (best 0.58) |
| O60678 | AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 3 (O60678) | predicted | A | — | — |
Ligands
- DVS · 5'-S-[3-(N'-benzylcarbamimidamido)propyl]-5'-thioadenosine · in 1 record
- GV3 · 5'-S-[3-(N'-phenylcarbamimidamido)propyl]-5'-thioadenosine · in 1 record
- GXF · 5'-S-{3-[N'-(4'-chloro[1,1'-biphenyl]-3-yl)carbamimidamido]propyl}-5'-thioadenosine · in 1 record
- HIY · 5'-S-[2-(phenylcarbamamido)ethyl]-5'-thioadenosine · in 1 record
- SO4 · Sulfate ion · in 1 record
- YVU · 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine · in 1 record
Experiment against prediction
- 3SMQ chain A against the predicted model O60678: TM-score 1.00, RMSD 0.32 Å
- 3SMQ chain A against the predicted model O60678: TM-score 1.00, RMSD 0.32 Å
- 8SHR chain A against the predicted model O60678: TM-score 1.00, RMSD 0.41 Å
- 8G2G chain B against the predicted model O60678: TM-score 1.00, RMSD 0.45 Å
- 8SIO chain A against the predicted model O60678: TM-score 1.00, RMSD 0.45 Å
- 8SIO chain B against the predicted model O60678: TM-score 0.99, RMSD 0.47 Å
- 8G2F chain A against the predicted model O60678: TM-score 0.99, RMSD 0.48 Å
- 8SHB chain A against the predicted model O60678: TM-score 0.99, RMSD 0.48 Å
- 8G2G chain A against the predicted model O60678: TM-score 0.99, RMSD 0.54 Å
- 2FYT chain A against the predicted model O60678: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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