UniProt O60658
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (O60658)
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (UniProt O60658), EC 3.1.4.53: 13 experimental structures on GenesisL1, 8 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D…
- UniProt
- O60658
- Protein
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase…
- EC
- 3.1.4.53
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 11 · 5 records with a druggable one
Structures
13 records of O60658 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ECM | Crystal structure of the unliganded PDE8A catalytic domain | x-ray diffraction | A | — | — |
| 3ECM | Crystal structure of the unliganded PDE8A catalytic domain | x-ray diffraction | A | — | — |
| 3ECN | Crystal structure of PDE8A catalytic domain in complex with IBMX | x-ray diffraction | A, B | — | — |
| 3ECN | Crystal structure of PDE8A catalytic domain in complex with ibmx | x-ray diffraction | A, B | — | — |
| 7CWA | Crystal structure of PDE8A catalytic domain in complex with clofarabine | x-ray diffraction | A | ZN, MG, CFB | 1 (best 0.72) |
| 7CWA | Crystal structure of PDE8A catalytic domain in complex with clofarabine | x-ray diffraction | A | ZN, MG, CFB | — |
| 7CWF | Crystal structure of PDE8A catalytic domain in complex with 2C | x-ray diffraction | A | ZN, MG, GJR | — |
| 7CWG | Crystal structure of PDE8A catalytic domain in complex with 3a | x-ray diffraction | A | ZN, MG, GJU | 2 (best 0.77) |
| 7CWG | Crystal structure of PDE8A catalytic domain in complex with 3A | x-ray diffraction | A | ZN, MG, GJU | — |
| 7VSL | Crystal structure of PDE8A catalytic domain in complex with 10 | x-ray diffraction | A | ZN, MG, 7XI | 3 (best 0.75) |
| 7VTV | Crystal structure of PDE8A catalytic domain in complex with 15 | x-ray diffraction | A | ZN, MG, 7ZZ | 3 (best 0.75) |
| 7VTX | Crystal structure of PDE8A catalytic domain in complex with 22 | x-ray diffraction | A | ZN, MG, 80D | 2 (best 0.77) |
| O60658 | AlphaFold monomer V2.0 prediction for high affinity camp-specific and ibmx-insensitive 3',5'-cyclic… | — | — | — |
Ligands
- MG · Magnesium ion · in 8 records
- ZN · Zinc ion · in 8 records
- CFB · 2-chloro-9-(2-deoxy-2-fluoro-B -D-arabinofuranosyl)-9H-purin-6-amine · in 2 records
- GJU · 9-[(1~{S})-1-[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]ethyl]-2-chloranyl-purin-6-amine · in 2 records
- 7XI · 2-chloro-9-(3-(2,2-difluoroethoxy)benzyl)-9H-purin-6-amine · in 1 record
- 7ZZ · 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(difluoromethoxy)benzyl)-9H-purin-6-amine · in 1 record
- 80D · 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(pyridin-4-yl)benzyl)-9H-purin-6-amine · in 1 record
- GJR · 9-[[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]methyl]-2-chloranyl-purin-6-amine · in 1 record
Elsewhere
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