UniProt O58187
Adenylosuccinate synthetase (O58187)
Adenylosuccinate synthetase (UniProt O58187), EC 6.3.4.4: 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O58187
- Protein
- Adenylosuccinate synthetase
- EC
- 6.3.4.4
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 20 · 3 records with a druggable one
Structures
5 records of O58187 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2D7U | Crystal structure of hypothetical adenylosuccinate synthetase, PH0438 from Pyrococcus horikoshii OT3 | x-ray diffraction | A | — | 1 (best 0.69) |
| 2D7U | Crystal structure of hypothetical adenylosuccinate synthetase, PH0438 from pyrococcus horikoshii OT3 | x-ray diffraction | A | — | — |
| 5K7X | Fully ligated Adenylosuccinate Synthetase from Pyrococcus horikoshii OT3 with GTP, IMP and Hadacidin | x-ray diffraction | A, B, C, D, E, F | GTP, IMP, HDA, MG | 18 (best 0.89) |
| 5K7X | Fully ligated adenylosuccinate synthetase from pyrococcus horikoshii OT3 with GTP, imp and hadacidin | x-ray diffraction | A, B, C, D, E, F | GTP, IMP, HDA, MG | — |
| O58187 | AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase (O58187) | predicted | A | — | 1 (best 0.77) |
Ligands
Experiment against prediction
- 5K7X chain A against the predicted model O58187: TM-score 1.00, RMSD 0.46 Å
- 5K7X chain A against the predicted model O58187: TM-score 1.00, RMSD 0.46 Å
- 2D7U chain A against the predicted model O58187: TM-score 0.99, RMSD 0.57 Å
- 2D7U chain A against the predicted model O58187: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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