UniProt O43914
TYRO protein tyrosine kinase-binding protein (O43914)
TYRO protein tyrosine kinase-binding protein (UniProt O43914): 9 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43914
- Protein
- TYRO protein tyrosine kinase-binding protein
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
10 records of O43914 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2L34 | Structure of the DAP12 transmembrane homodimer | solution nmr | A, B | — | — |
| 2L34 | Structure of the DAP12 transmembrane homodimer | solution nmr | A, B | — | — |
| 2L35 | Structure of the DAP12-NKG2C transmembrane heterotrimer | solution nmr | A, B | — | — |
| 2L35 | Structure of the DAP12-NKG2C transmembrane heterotrimer | solution nmr | A, B | — | — |
| 4WO1 | Crystal structure of the DAP12 transmembrane domain in lipid cubic phase | x-ray diffraction | A, B, C, D | — | — |
| 4WO1 | Crystal structure of the DAP12 transmembrane domain in lipid cubic phase | x-ray diffraction | A, B, C, D | — | — |
| 4WOL | Crystal Structure of the DAP12 transmembrane domain in lipidic cubic phase | x-ray diffraction | A, B, C | — | — |
| 4WOL | Crystal structure of the DAP12 transmembrane domain in lipidic cubic phase | x-ray diffraction | A, B, C | — | — |
| 7Q5W | The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide | x-ray diffraction | GGG, HHH, III, JJJ, KKK, LLL | — | 7 (best 0.79) |
| O43914 | AlphaFold monomer V2.0 prediction for tyro protein tyrosine kinase- binding protein (O43914) | predicted | A | — | — |
Experiment against prediction
- 4WOL chain A against the predicted model O43914: TM-score 0.83, RMSD 0.82 Å
- 4WOL chain A against the predicted model O43914: TM-score 0.83, RMSD 0.82 Å
- 4WO1 chain A against the predicted model O43914: TM-score 0.78, RMSD 1.11 Å
- 4WO1 chain A against the predicted model O43914: TM-score 0.78, RMSD 1.11 Å
- 2L35 chain B against the predicted model O43914: TM-score 0.69, RMSD 1.87 Å
- 2L35 chain B against the predicted model O43914: TM-score 0.69, RMSD 1.87 Å
- 4WOL chain B against the predicted model O43914: TM-score 0.69, RMSD 1.40 Å
- 4WOL chain B against the predicted model O43914: TM-score 0.69, RMSD 1.40 Å
- 2L34 chain A against the predicted model O43914: TM-score 0.65, RMSD 2.18 Å
- 2L34 chain A against the predicted model O43914: TM-score 0.65, RMSD 2.18 Å
Elsewhere
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