UniProt O43683
Mitotic checkpoint serine/threonine-protein kinase BUB1 (O43683)
Mitotic checkpoint serine/threonine-protein kinase BUB1 (UniProt O43683), EC 2.7.11.1: 16 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment against…
- UniProt
- O43683
- Protein
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- EC
- 2.7.11.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
17 records of O43683 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LAH | Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain… | solution nmr | A | — | — |
| 2LAH | Solution NMR structure of mitotic checkpoint SERINE/THREONINE-protein kinase BUB1 N-terminal domain… | solution nmr | A | — | — |
| 4A1G | The crystal structure of the human Bub1 TPR domain in complex with the KI motif of Knl1 | x-ray diffraction | A, B, C, D | — | — |
| 4A1G | The crystal structure of the human BUB1 tpr domain in complex with the ki motif of KNL1 | x-ray diffraction | A, B, C, D | — | — |
| 4QPM | Structure of Bub1 kinase domain | x-ray diffraction | A, B | — | — |
| 4QPM | Structure of BUB1 kinase domain | x-ray diffraction | A, B | — | — |
| 4R8Q | Structure and substrate recruitment of the human spindle checkpoint kinase bub1 | x-ray diffraction | A | — | — |
| 4R8Q | Structure and substrate recruitment of the human spindle checkpoint kinase BUB1 | x-ray diffraction | A | — | — |
| 5DMZ | Structure of human Bub1 kinase domain phosphorylated at Ser969 | x-ray diffraction | A, B | ADP, MG | — |
| 5DMZ | Structure of human BUB1 kinase domain phosphorylated at SER969 | x-ray diffraction | A, B | — | — |
| 6F7B | Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032 | x-ray diffraction | A | CVQ, MG | — |
| 6F7B | Crystal structure of the human BUB1 kinase domain in complex with bay 1816032 | x-ray diffraction | A | CVQ, MG | — |
| 7B1F | Orthorhombic P212121 structure of human MAD1 C-terminal domain in complex with phosphorylated BUB1… | x-ray diffraction | C, D | — | — |
| 7B1H | Monoclinic P21 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1 CD1… | x-ray diffraction | C, D, G, H | — | 3 (best 0.69) |
| 7B1H | Monoclinic P21 structure of human MAD1 C-terminal domain in complex with phosphorylated BUB1 CD1… | x-ray diffraction | C, D, G, H | — | — |
| 7B1J | Orthorhombic P21212 structure of human MAD1 C-terminal domain in complex with phosphorylated BUB1… | x-ray diffraction | C, D | — | — |
| O43683 | AlphaFold monomer V2.0 prediction for mitotic checkpoint SERINE/THREONINE-protein kinase BUB1… | predicted | A | — | — |
Ligands
Experiment against prediction
- 4QPM chain A against the predicted model O43683: TM-score 0.99, RMSD 0.80 Å
- 4QPM chain A against the predicted model O43683: TM-score 0.99, RMSD 0.80 Å
- 5DMZ chain B against the predicted model O43683: TM-score 0.99, RMSD 0.97 Å
- 5DMZ chain B against the predicted model O43683: TM-score 0.99, RMSD 0.97 Å
- 5DMZ chain A against the predicted model O43683: TM-score 0.99, RMSD 1.00 Å
- 5DMZ chain A against the predicted model O43683: TM-score 0.99, RMSD 1.00 Å
- 4QPM chain B against the predicted model O43683: TM-score 0.98, RMSD 0.93 Å
- 4QPM chain B against the predicted model O43683: TM-score 0.98, RMSD 0.93 Å
- 4R8Q chain A against the predicted model O43683: TM-score 0.98, RMSD 0.88 Å
- 4R8Q chain A against the predicted model O43683: TM-score 0.98, RMSD 0.88 Å
Elsewhere
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