UniProt O43614
Orexin receptor type 2 (O43614)
Orexin receptor type 2 (UniProt O43614): 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43614
- Protein
- Orexin receptor type 2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 8 · 2 records with a druggable one
Structures
11 records of O43614 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4S0V | Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant | x-ray diffraction | A | — | — |
| 4S0V | Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant | x-ray diffraction | A | — | — |
| 5WQC | Crystal structure of human orexin 2 receptor bound to the selective antagonist empa determined by… | x-ray diffraction | A | 7MA, OLA | — |
| 5WS3 | Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by… | x-ray diffraction | A | 7MA, OLA | 4 (best 0.82) |
| 5WS3 | Crystal structures of human orexin 2 receptor bound to the selective antagonist empa determined by… | x-ray diffraction | A | 7MA, OLA | — |
| 6TPG | Crystal structure of the orexin-2 receptor in complex with empa at 2.74 a resolution | x-ray diffraction | A | 7MA, OLA | — |
| 6TPJ | Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution | x-ray diffraction | A, B | OLA, SUV, NH4 | — |
| 6TPJ | Crystal structure of the orexin-2 receptor in complex with suvorexant at 2.76 a resolution | x-ray diffraction | A, B | OLA, SUV, NH4 | — |
| 6TPN | Crystal structure of the orexin-2 receptor in complex with HTL6641 at 2.61 a resolution | x-ray diffraction | A | NU8, NO3, OLA | — |
| 7SQO | Structure of the orexin-2 RECEPTOR(OX2R) bound to tak-925, gi and SCFV16 | electron microscopy | R | OLA, A6F | — |
| O43614 | AlphaFold monomer V2.0 prediction for orexin receptor type 2 (O43614) | predicted | A | — | 4 (best 0.80) |
Ligands
- OLA · Oleic acid · in 8 records
- 7MA · N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl) sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide · in 4 records
- NH4 · Ammonium ion · in 2 records
- SUV · [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl) phenyl]methanone · in 2 records
- A6F · methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate · in 1 record
- NO3 · Nitrate ion · in 1 record
- NU8 · 2-(5,6-dimethoxypyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-E][1, 2,4]thiadiazin-3-one · in 1 record
Experiment against prediction
- 7SQO chain R against the predicted model O43614: TM-score 0.91, RMSD 2.38 Å
- 5WS3 chain A against the predicted model O43614: TM-score 0.66, RMSD 2.03 Å
- 5WS3 chain A against the predicted model O43614: TM-score 0.66, RMSD 2.03 Å
- 5WQC chain A against the predicted model O43614: TM-score 0.66, RMSD 2.02 Å
- 6TPJ chain B against the predicted model O43614: TM-score 0.65, RMSD 2.27 Å
- 6TPJ chain B against the predicted model O43614: TM-score 0.65, RMSD 2.27 Å
- 6TPJ chain A against the predicted model O43614: TM-score 0.65, RMSD 2.12 Å
- 6TPJ chain A against the predicted model O43614: TM-score 0.65, RMSD 2.12 Å
- 6TPN chain A against the predicted model O43614: TM-score 0.64, RMSD 2.59 Å
- 6TPG chain A against the predicted model O43614: TM-score 0.64, RMSD 2.52 Å
Elsewhere
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