UniProt O43566
Regulator of G-protein signaling 14 (O43566)
Regulator of G-protein signaling 14 (UniProt O43566): 8 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43566
- Protein
- Regulator of G-protein signaling 14
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
9 records of O43566 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JNU | Solution structure of the RGS domain of human RGS14 | solution nmr | A | — | — |
| 2JNU | Solution structure of the rgs domain of human RGS14 | solution nmr | A | — | — |
| 2XNS | Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco… | x-ray diffraction | C, D | — | — |
| 2XNS | Crystal structure of human G alpha I1 bound to a designed helical peptide derived from the goloco… | x-ray diffraction | C, D | — | — |
| 3ONW | Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif. | x-ray diffraction | C, D | — | — |
| 3ONW | Structure of a G-alpha-I1 mutant with enhanced affinity for the RGS14 goloco motif. | x-ray diffraction | C, D | — | — |
| 3QI2 | A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco | x-ray diffraction | C, D | — | — |
| 3QI2 | A galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 goloco | x-ray diffraction | C, D | — | — |
| O43566 | AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 14 (O43566) | predicted | A | — | 1 (best 0.29) |
Experiment against prediction
- 2JNU chain A against the predicted model O43566: TM-score 0.89, RMSD 2.32 Å
- 2JNU chain A against the predicted model O43566: TM-score 0.89, RMSD 2.32 Å
- 3QI2 chain C against the predicted model O43566: TM-score 0.43, RMSD 2.51 Å
- 3QI2 chain C against the predicted model O43566: TM-score 0.43, RMSD 2.51 Å
- 3ONW chain D against the predicted model O43566: TM-score 0.42, RMSD 2.63 Å
- 3ONW chain D against the predicted model O43566: TM-score 0.42, RMSD 2.63 Å
- 2XNS chain C against the predicted model O43566: TM-score 0.39, RMSD 2.91 Å
- 2XNS chain C against the predicted model O43566: TM-score 0.39, RMSD 2.91 Å
- 3ONW chain C against the predicted model O43566: TM-score 0.35, RMSD 3.24 Å
- 3ONW chain C against the predicted model O43566: TM-score 0.35, RMSD 3.24 Å
Elsewhere
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