UniProt O43314
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (O43314)
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (UniProt O43314), EC 2.7.4.21, 2.7.4.24: 40 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 19 pockets. Binding sites…
- UniProt
- O43314
- Protein
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
- EC
- 2.7.4.21, 2.7.4.24
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 19 · 5 records with a druggable one
Structures
41 records of O43314 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3T54 | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T54 | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T7A | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T7A | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T99 | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T99 | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9A | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9A | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9B | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9B | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9C | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9C | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9D | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9D | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9E | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9E | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9F | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 3T9F | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 4HN2 | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 4HN2 | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 4NZM | Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PA-InsP5 | x-ray diffraction | A | — | — |
| 4NZM | Crystal structure of the catalytic domain of PPIP5K2 in complex with amppnp and 5-pa-INSP5 | x-ray diffraction | A | — | — |
| 4NZN | Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2-O-BN-5-PA-INSP4 | x-ray diffraction | A | — | — |
| 4NZN | Crystal structure of the catalytic domain of PPIP5K2 in complex with amppnp and 2-O-bn-5-pa-INSP4 | x-ray diffraction | A | — | — |
| 4NZO | Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2,5-DI-O-BN-INSP4 | x-ray diffraction | A | — | — |
| 4NZO | Crystal structure of the catalytic domain of PPIP5K2 in complex with amppnp and 2,5-di-O-bn-INSP4 | x-ray diffraction | A | — | — |
| 4Q4C | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 4Q4C | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 4Q4D | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 4Q4D | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 5BYA | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 5BYB | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 5BYB | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 5DGH | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | ANP, 5A3, MG | 1 (best 0.80) |
| 5DGH | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 5DGI | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | ADP, 5A2, MG | 1 (best 0.81) |
| 5DGI | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | — | — |
| 6N5C | Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PCF2Am-InsP5 | x-ray diffraction | A | ANP, MG, KDJ | 1 (best 0.80) |
| 6N5C | Crystal structure of the catalytic domain of PPIP5K2 in complex with amppnp and 5-PCF2AM-INSP5 | x-ray diffraction | A | ANP, MG, KDJ | — |
| 8G9E | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2… | x-ray diffraction | A | ANP, YUT, MG | 1 (best 0.80) |
| O43314 | AlphaFold monomer V2.0 prediction for inositol hexakisphosphate and… | predicted | A | — | 15 (best 0.80) |
Ligands
- MG · Magnesium ion · in 5 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 4 records
- KDJ · (1,1-difluoro-2-oxo-2-{[(1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl) phosphonic acid · in 2 records
- 5A2 · 3,5-di-methylenebisphosphonate inositol tetrakisphosphate · in 1 record
- 5A3 · Methylenebisphosphonate inositol pentakisphosphate · in 1 record
- ADP · Adenosine-5'-diphosphate · in 1 record
- YUT · {difluoro[(R)-hydroxy{[(1s,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphoryl]methyl}phosphonic acid · in 1 record
Experiment against prediction
- 3T9B chain A against the predicted model O43314: TM-score 1.00, RMSD 0.30 Å
- 3T9B chain A against the predicted model O43314: TM-score 1.00, RMSD 0.30 Å
- 3T7A chain A against the predicted model O43314: TM-score 1.00, RMSD 0.31 Å
- 3T7A chain A against the predicted model O43314: TM-score 1.00, RMSD 0.31 Å
- 5BYA chain A against the predicted model O43314: TM-score 1.00, RMSD 0.38 Å
- 5DGI chain A against the predicted model O43314: TM-score 1.00, RMSD 0.41 Å
- 5DGI chain A against the predicted model O43314: TM-score 1.00, RMSD 0.41 Å
- 8G9E chain A against the predicted model O43314: TM-score 1.00, RMSD 0.43 Å
- 4Q4D chain A against the predicted model O43314: TM-score 1.00, RMSD 0.45 Å
- 4Q4D chain A against the predicted model O43314: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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