UniProt O38893
Protease (O38893)
Protease (UniProt O38893): 7 experimental structures on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O38893
- Protein
- Protease
- Experimental structures
- 7
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 4 · 0 records with a druggable one
Structures
7 records of O38893 in the MolNFT archive: 7 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6MK9 | X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with GRL-121 | x-ray diffraction | A, B | 7O7 | — |
| 6MK9 | X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with grl-121 | x-ray diffraction | A, B | 7O7 | — |
| 6MKL | X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with grl-142 | x-ray diffraction | A, B | 7OA | — |
| 6OGL | X-ray crystal structure of darunavir-resistant HIV-1 protease (P51) in complex with grl-003 | x-ray diffraction | A | JDV | — |
| 6OGT | X-ray crystal structure of darunavir-resistant HIV-1 protease (P51) in complex with GRL-001 | x-ray diffraction | A | JDY | 2 (best 0.49) |
| 6OGT | X-ray crystal structure of darunavir-resistant HIV-1 protease (P51) in complex with grl-001 | x-ray diffraction | A | JDY | — |
| 9CTX | X-ray crystal structure of multi-drug resistant HIV-1 protease (P51) in complex with Darunavir | x-ray diffraction | A | 017 | 2 (best 0.46) |
Ligands
- 7O7 · (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl {(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
- JDY · (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3-fluorophenyl)-3-hydroxybutan-2-yl]carbamate · in 2 records
- 017 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1s,2r)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate · in 1 record
- 7OA · (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate · in 1 record
- JDV · (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]carbamate · in 1 record
Elsewhere
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