UniProt O35956
Solute carrier family 22 member 6 (O35956)
Solute carrier family 22 member 6 (UniProt O35956): 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O35956
- Protein
- Solute carrier family 22 member 6
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 31 · 8 records with a druggable one
Structures
9 records of O35956 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8BVR | Cryo-EM structure of rat SLC22A6 in the apo state | electron microscopy | A | PO4 | 4 (best 0.80) |
| 8BVS | Cryo-EM structure of rat SLC22A6 bound to tenofovir | electron microscopy | A | TFO, CL | — |
| 8BVT | Cryo-EM structure of rat SLC22A6 bound to probenecid | electron microscopy | A | RTO | 7 (best 0.82) |
| 8BW7 | Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid | electron microscopy | A | AKG, CL | 3 (best 0.78) |
| 8OMU | Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state | electron microscopy | A | — | 3 (best 0.80) |
| 8SDU | Structure of rat organic anion transporter 1 (OAT1) | electron microscopy | A | — | 3 (best 0.79) |
| 8SDY | Structure of rat organic anion transporter 1 (OAT1) in complex with para-aminohippuric acid (PAH) | electron microscopy | A | ZWD | 3 (best 0.80) |
| 8SDZ | Structure of rat organic anion transporter 1 (OAT1) in complex with probenecid | electron microscopy | A | RTO | 3 (best 0.82) |
| O35956 | AlphaFold monomer V2.0 prediction for solute carrier family 22 member 6 (O35956) | predicted | A | — | 5 (best 0.82) |
Ligands
Experiment against prediction
- 8SDZ chain A against the predicted model O35956: TM-score 0.99, RMSD 0.77 Å
- 8SDU chain A against the predicted model O35956: TM-score 0.99, RMSD 0.92 Å
- 8SDY chain A against the predicted model O35956: TM-score 0.99, RMSD 0.96 Å
- 8BVS chain A against the predicted model O35956: TM-score 0.98, RMSD 1.14 Å
- 8BW7 chain A against the predicted model O35956: TM-score 0.98, RMSD 1.15 Å
- 8BVR chain A against the predicted model O35956: TM-score 0.98, RMSD 1.16 Å
- 8OMU chain A against the predicted model O35956: TM-score 0.98, RMSD 1.19 Å
- 8BVT chain A against the predicted model O35956: TM-score 0.97, RMSD 1.60 Å
Elsewhere
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